Product Description

 

Introduction

 

Appearance and Properties: White Fine Crystal

Density: 1.38 g / cm3

 Melting Point: 160-163 ° C (lit.)

Boiling Point: 453.1ºC at 760 mmHg

Flash Point: 227.8ºC

 

For food, medicine, cosmetics and other industries; organic synthesis intermediates, food additives

1.L-Pyroglutamic Acid is cardio protection; prevention of atherosclerosis

2.L-Pyroglutamic Acid is cancer prevention

3.L-Pyroglutamic Acid is prevention of tooth decay and gum disease

4.L-Pyroglutamic Acid is kidney function improvement

5.L-Pyroglutamic Acid anti-platelet aggregation to prevent blood clotting

6.L-Pyroglutamic Acid is liver protection

7.L-Pyroglutamic Acid is protection and restoration of immune system

8.L-Pyroglutamic Acid is inhibition of infectious pathogens

 

 

Function

 

Pyroglutamic acid is a kind of based 5-oxo-proline. It is produced by the dehydration and formation of intramolecular amide bond between the α-NH2 group and γ-hydroxy of glutamic acid; the molecule can also be produced from glutamine by losing its intramolecular amine group. The condition of glutathione synthetase deficiency can cause the anemia of pyroglutamic acid with a series of clinical symptoms. Pyroglutamic acid anemia is a kind of organic acid metabolic disorder disease caused by glutathione synthetase hyperlipidemia. Clinical manifestations: disease onset occurs within 12 to 24 hours of born with progressive hemolysis, jaundice, chronic metabolic acidosis, mental retardation; urine containing pyroglutamic acid, lactic acid, α-deoxy-4-hydroxyphenyl acetyl acid lactone. For treatment, based on the actual symptoms, pay attention to adjust the diet after yearling.
 

Application

 Human skin contains a kind of moisturizing functional water-soluble substances-the natural moisturizing factor, roughly consisting of amino acids (40%), pyroglutamic acid (12%), inorganic salts (Na, K, Ca, containing 18.5% Mg, etc.), and other organic matter (including 29.5%). So, pyroglutamic acid is one of the major components of natural moisturizing factor of the skin, its moisturizing ability is far stronger than glycerin and propylene glycol. Moreover, it is non-toxic, non-irritating, and is an excellent raw material for modern skin care, and hair care cosmetics. Pyroglutamic acid also has inhibitory effect on the tyrosine oxidase activity, and thus preventing "melanoidins" substance from being deposited in the skin, and having a whitening effect on the skin. It has a keratin softening effect which can be used in nail cosmetics. In addition to be applied in cosmetics, L-pyroglutamic acid derivatives can also have reaction with a number of other organic compounds for synthesis of derivatives. It also has some special effect on the surface activity and brilliant effect. Moreover, it can also be used as surfactants for detergents; as a chemical reagent, it can be used for the resolution of racemic amines; it can also be used as a kind of organic intermediates.
L-pyroglutamic acid has its scientific name being L-2-pyrrolidone-5-carboxylic acid. Precipitation from ethanol and petroleum ether mixture were colorless orthorhombic bipyramid crystals with the melting temperature being 162~163 °C. It is soluble in water, alcohol, acetone and acetic acid, slightly soluble in ethyl acetate, and insoluble in ether. Specific rotation-11.9 ° (c = 2, H2O). It is produced from 42% aqueous solution of glutamic acid which subjects to heating dehydration, concentration, crystallization, washing and drying to obtain L-pyroglutamic acid.

Specification

 

 

Item	Specifications	Results
Appearance	Off-White crystalline powder	Conforms
Specific rotation(a)D20 (C=2,H20)	-10.5°to -11.8°	-11.6°
Melting point (°C)	158°C to 161°C	159.5°C
Chloride (C1)	NMT 0.02%	0.01%
Ammonium (NH4)	NMT  0.02%	<0.02%
Sulfate (SO4)	NMT  0.05%	0.005%
Heavy metals (Pb)	NMT 10ppm	10ppm
Iron(Fe)	NMT  20ppm	8ppm
Arsenic (As2O3)	NMT 1ppm	<1ppm
Loss on drying	NMT  0.50%	0.39%
Residue on ignition	NMT  0.2%	0.07%
Assay	98.0-101.0%	99.3%