Pharmaceutical Raw Material CAS 877399-52-5 Crizotinib Powder High Purity CAS NO.877399-52-5

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Despcription:
Product Name: Crizotinib
CAS:877399-52-5
MF:C21H22Cl2FN5O
MW:450.343
EINECS:638-814-9
Mol File:877399-52-5.mol 
Melting point:192 °C
Boiling point:599.2±50.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. room temp
pka9.81±0.10(Predicted)
form: powder
color: white to tan

Application:
Crizotinib is a dual ATP competitive inhibitor of tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) and ALK (cellular IC50=20 nM), both of which are important targets for cancer chemotherapy. When crizotinib was tested for selectivity versus other kinases it was found to have enzyme IC50's within 100-fold multiples of c-MET for 13 of the 120 kinases tested. In cellular assays, crizotinib was found to inhibit RON (recepteur d'origine nantais) kinase with a 10-fold selectivity window over c-MET.
Chemical PropertiesWhite Solid
UsesA potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). A potential antitumor agent.
UsesCrizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
UsesPF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley