High quality 864070-44-0 Empagliflozin in factory CAS NO.864070-44-0

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Quack Detail for EMpagliflozin
 

Empagliflozin (trade name Jardiance) is really a drug from the gliflozin class, approved for that treatments for diabetes type 2 in adults in 2014. It turned out put together by Boehringer Ingelheim and Eli Lilly and Company.
Empagliflozin is an inhibitor with the sodium glucose co-transporter-2 (SGLT-2), and results in sugar in the blood being excreted by the kidneys and eliminated in urine.

About the Empagliflozin

Empagliflozin is really a selective inhibitor of SGLT-2 with IC50 value of 3.1 nM .
Sodium glucose cotransporter-2 (SGLT-2) is part of sodium glucose co-transporter family and plays a pivotal role in glucose reabsorption in the kidney .

Empagliflozin is a potent SGLT-2 inhibitor and it has a high amount of selectivity over SGLT-1, 4, 5 and 6 than other reported SGLT-2 inhibitors. When tested using a panel of human cell lines over-expressed SGLT-1, 2, 4, 5 and 6,

Empagliflozin treatment competitively bind to SGLT-2 over glucose at low dose . In human proximal tublular cell (PTC) cell line HK2 cells, Empagliflozin answer to 72 h inhibits the expression of SGLT-2 which reversed high glucose induced TLR4 expression, NF-κB binding, IL-6 secretion, AP-1 binding and CIV expression .

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