Ciprofloxacin hydrochloride 86393-32-0 treat a wide variety of infections CAS NO.86393-32-0

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Name: Ciprofloxacin hydrochloride

Molecular Formula: C17H18FN3O3. ClH. H2O

CAS: 86393-32-0

Synonyms: Ciprofloxacin hcl

Appearance: White or yellowish crystalline powder

Molecular Weight: 385.82

Boiling Point: 581.8 oC at 760 mmHg

Melting Point: 318-320 oC

Flash Point: 305.6 oC

Storage Temperature: 0-6° C

COA:

Ciprofloxacin (INN) is an antibiotic useful for the treatment of a number of bacterial infections. It is a second-generation fluoroquinolone. Its spectrum of activity includes most strains of bacterial pathogens responsible for respiratory, urinary tract, gastrointestinal, and abdominal infections, including Gram-negative (Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, and Pseudomonas aeruginosa), and Gram-positive (methicillin-sensitive, but not methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, Staphylococcus epidermidis, Enterococcus faecalis, and Streptococcus pyogenes) bacterial pathogens.

Medical uses:

Ciprofloxacin is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid.

Ciprofloxacin only treats bacterial infections; It does not treat viral infections such as the common cold. Although for certain uses including acute sinusitis, lower respiratory tract infections and uncomplicated gonorrhea, ciprofloxacin is not considered a first-line agent.

Ciprofloxacin occupies an important role in treatment guidelines issued by major medical societies for the treatment of serious infections, especially those likely to be caused by Gram-negative bacteria, including Pseudomonas aeruginosa. For example, ciprofloxacin in combination with metronidazole is one of several first-line antibiotic regimens recommended by the Infectious Disease Society of America for the treatment of community-acquired abdominal infections in adults. It also features prominently in treatment guidelines for acute pyelonephritis, complicated or hospital-acquired urinary tract infection, acute or chronic prostatitis, certain types of endocarditis, certain skin infections, and prosthetic joint infections.

In other cases, treatment guidelines are more restrictive, recommending in most cases that older, narrower-spectrum drugs be used as first-line therapy for less severe infections to minimize fluoroquinolone-resistance development. For example, the Infectious Disease Society of America recommends the use of ciprofloxacin and other fluoroquinolones in urinary tract infections be reserved to cases of proven or expected resistance to narrower-spectrum drugs such as nitrofurantoin or trimethoprim-sulfamethoxazole. The European Association for Urology recommends ciprofloxacin as an alternative regimen for the treatment of uncomplicated urinary tract infections, but cautions that the potential for "adverse events have to be considered".

Ciprofloxacin is an antibiotic used to treat a number of bacterial infections.This includes bone and joint infections, intra abdominal infections, certain type of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others.For some infections it is used in addition to other antibiotics.It can be taken by mouth or used intravenously.

Ciprofloxacin is a broad-spectrum antibiotic active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV,enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.

Ciprofloxacin is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid.

Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses including acute sinusitis, lower respiratory tract infections and uncomplicated gonorrhea, ciprofloxacin is not considered a first-line agent.

Side Effects:

Common side effects include nausea, vomiting, diarrhea, and rash.Ciprofloxacin increases the risk of tendon rupture and worsening muscle weakness in people with the neurological disorder myasthenia gravis.Rates of side effects appear to be higher than some groups of antibiotics such as cephalosporins but lower than others such as clindamycin.Studies in other animals raise concerns regarding use in pregnancy.No problems were identified, however, in the children of a small number of women who took the medication.It appears to be safe during breastfeeding.It is a second-generation fluoroquinolone with a broad spectrum of activity that usually results in the death of the bacteria.