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Ketotifen Fumarate Manufacturer 859-18-7 For Antiallergic CAS NO.859-18-7
- Min.Order: 10 Gram
- Payment Terms: T/T,
- Product Details
Keywords
- 99% Ketotifen Fumarate
- Ketotifen Fumarate Manufacturer
- For Antiallergic
Quick Details
- ProName: Ketotifen Fumarate Manufacturer 859-18...
- CasNo: 859-18-7
- Molecular Formula: C23H23NO5S
- Appearance: White Powder
- Application: It Can Be Used As Pharmaceutical Inte...
- DeliveryTime: 2-4 days after confirming your payment...
- PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
- Port: Wuhan
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Store in sealed containers at cool & d...
- Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
- LimitNum: 10 Gram
Superiority
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
4. Warm after-sale service Any of your question would be solved for the first as soon as possible.
Details
| Ketotifen fumarate Basic information |
| Product Name: | Ketotifen fumarate |
| Synonyms: | zaditen;Ketotifen Hydrogen FuMarate, EP;4,9-Dihydro-4-(1-Methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-2-Butenedioate;Totifen;Zasten;Ketotifen FuMarate API;4-(1-Methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fuMarate;ketotifen fuMarat |
| CAS: | 34580-14-8 |
| MF: | C23H23NO5S |
| MW: | 425.5 |
| EINECS: | 252-100-0 |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Pharmaceutical raw material;SERC;Other APIs;Antiallergic agents;Antagonists;Histaminergics;Neurotransmitters;Histamine receptor |
| Mol File: | 34580-14-8.mol |
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| Ketotifen fumarate Chemical Properties |
| Melting point | 192 C |
| storage temp. | Store at RT |
| solubility | Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in acetonitrile. |
| form | neat |
| PH | pH (10g/l, 25℃) : 3.0～4.0 |
| Water Solubility | Soluble in water (10 mg/ml), DMSO (100 mM), and methanol. |
| λmax | 297nm(MeOH)(lit.) |
| Merck | 14,5307 |
| CAS DataBase Reference | 34580-14-8(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,T |
| Risk Statements | 22-36/37/38-23/24/25 |
| Safety Statements | 36-45-36/37/39-26 |
| WGK Germany | 3 |
| RTECS | DE8260000 |
| HS Code | 29349990 |
| Clinical application | It has been more than 20 years since ketotifen fumarate have been applied to the prevention and treatment of asthma and childhood asthma. It is a kind of drug with dual effect of both prevention and treatment in the prevention and treatment of asthma and childhood asthma. It should be particularly noted that ketotifen had ever taken as the long-term controlling drug of asthma and childhood long-term asthma and was subject to wide application in many countries. Since the early 1980s, ketotifen fumarate had already been applied in Western Europe, Asia, and China for the prevention and treatment of asthma and asthma in children. But since entering into 21st century, the annual applied amount has decreased year by year. Because of its side effect of inhibition of the central nervous system, its oral tablet currently has still not approved by the FDA and thus failing to enter the US market with only ketotifen fumarate eye drops (ZADITOR) had been approved by the FDA in 1999. Recent studies have also shown the effectiveness of ketotifen asthma still demands further studies. Moreover, ketotifen fumarate has several additional advantages. First, it can cause sleepiness of the schoolchildren and thus being able to affect their academic performance; second, it can also do harm to the mental development of infants and young children. Thirdly, it is also be able to affect the metabolism of sustained-release tea and thus negatively affecting its anti-inflammatory effects of theophylline. For all the above points, it is not recommended by the GINA (affiliated organization of WHO) to apply ketotifen fumarate for the treatment and prevention of asthma and childhood asthma. But from the perspective of clinical economics, ketotifen fumarate is a suitable anti-allergic drug for being applied in developing countries and rural areas for treating asthma and childhood asthma with certain efficacy due to its relative low price. |
| Side Effects | The most severe side effect of ketotifen fumarate is its inhibitory effect on central nerve system such as causing sleepiness or fatigue, weakness. This side effect is more significant in adults and is one of the major reasons for limiting its clinical application. The resulted sense of lethargy or fatigue, weakness may reduce the life quality of asthma patients as well as children with asthma. Usually, after continuous administration of 1-4 weeks, the side effect of suppression of the central nerve system can significantly reduce and even gradually disappear. Clinical observation has found that combination with theophylline can reduce the central nerve inhibitory effect of ketotifen fumarate as well as offset the stimulus effect on central nerve system of theophylline. But it still demands further observation to demonstrate whether there exist synergistic anti-inflammatory between them. Clinical observations have already confirmed children who administering ketotifen fumarate usually get no significant inhibition of the central nervous system and at most cause only the lower concentration of children’s mind. This is still true even the children subject to an adult dose. However, this mechanism is still unclear. In the clinical observation on the asthma adults patients as well as children patients who subject to 2-year continuous oral administration, wood et al have confirmed that long-term administration of ketotifen fumarate caused no other serious side effects without affecting the liver and kidney function as well as peripheral blood cell counts. It is also not easy to produce drug resistance issues. Usually after continuous oral administration of ketotifen fumarate for six weeks, we can begin to gradually withdraw or reduce the amount of bronchial spasm agent or corticosteroids. Discontinuation of treatment after long-term treatment has not resulted in rebound phenomenon. Therefore, the comprehensive evaluation of the drug is that: ketotifen fumarate is an anti-asthma drug with central nervous inhibition effect (this side effect can gradually adapt), but is relatively safe and effective with certain anti-inflammatory properties and being relatively inexpensive. However, because it has not approved by the FDA, it should be applied with caution in clinical practice. |
| Chemical Properties | Off-White Solid |
| Uses | vasodilator |
| Uses | Antiasthmatic; antiallergic. |