High Quality Best Price of Temozolomide CAS 85622-93-1 Anti-Cancers Powder CAS NO.85622-93-1

Min.Order: 100 Gram
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Product Details

Keywords

85622-93-1
Temozolomide
C6H6N6O2

Quick Details

ProName: High Quality Best Price of Temozolomid...
CasNo: 85622-93-1
Molecular Formula: C6H6N6O2
Appearance: White Powder
Application: Used as a pharmaceutical intermediates...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 20000 Kilogram/Day
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 100 Gram

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High Quality Best Price of Temozolomide CAS 85622-93-1 Anti-Cancers Powder

Temozolomide: 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide
Molecular Structure:
Molecular Formula: C6H6N6O2
Molecular Weight: 194.15
CAS No.: 85622-93-1
Uses: Antitumor Drug
Purity: >99%
Temozolomide is a chemotherapy drug used to treat certain types of brain tumours called glioblastoma multiforme or anaplastic astrocytoma.
Temozolomide COA

Test items	Requirements	Results
Description	A White or off-white crystalline powder; odorless; tasted bitter.	Complies
Solubility	Slightly soluble in water, very slightly soluble in dehydrated alcohol, soluble in DMF and very soluble DMSO.	Complies
Identification
A. IR	A: Conform to reference standard	Conforms
B. Chemical Property	B: Dissolve 0.1g the sample with 10ml water, add 5ml dinitro-phenyl-hydrazine, should have marron precipitate.	Positive
C. HPLC	C: The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation	Conforms
Loss on drying	≤ 1.0%.	0.21%
Residue on ignition	≤ 0.1%.	0.07%
Heavy metals	≤ 0.002%.	Complies
Chloride	≤ 0.002%.	Complies
Impurities by HPLC Any impurity(Max) Total impurities	≤ 0.1%. ≤ 0.3%.	0.042% 0.08%
Residual solvents Ethyl acetate Alcohol DMSO	≤ 0.5%. ≤ 0.5%. ≤ 0.5%.	Complies Complies Complies
Assay (HPLC)	98.5%~102.0%	99.80%

Temozolomide Description
Temozolomide is an antitumor, antiangiogenic compound that has been shown to work by alkylating DNA, typically through addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis;
however, some cells are able to repair this damage via the enzymes O-6-methylguanine-DNA methyltransferase (MGMT). As a consequence, temozolomide is far more efficacious in tumor cells that have silenced this repair enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint, which mightalso play a role in its cytotoxicity.

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High Quality Best Price of Temozolomide CAS 85622-93-1 Anti-Cancers Powder