China Supply Antibacterial Pharmaceuticals Clarithromycin CAS 81103-11-9 CAS NO.81103-11-9

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China Supply Antibacterial Pharmaceuticals Clarithromycin CAS 81103-11-9

Clarithromycin Basic information

Product Name:	Clarithromycin
Synonyms:	6-o-methyl-erythromyci;6-o-methylerythromycina;clathromycin;te-03;TE-031;6-O-METHYLERYTHROMYCIN;6-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYL-OXAN-2-YL)OXY-14-ETHYL-12,13-DIHYDROXY-4-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-OXAN-2-YL)OXY-7-METHOXY-3,5,7,9,11,13-HEXAMETHYL-1-OXACYCLOTETRADECANE-2,10-DIONE;6-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYLTETRAHYDROPYRAN-2-YL-OXY)-14-ETHYL-12,13-DIHYDROXY-4-(5-HYDROXY)
CAS:	81103-11-9
MF:	C38H69NO13
MW:	747.95
EINECS:	1806241-263-5
Product Categories:	Antibiotics;APIs;Antibiotics for Research and Experimental Use;Biochemistry;Macrolides (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals;Pharmaceuticals;API's;1694 Pharmaceuticals&Personal Care Products;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;MacrolidesEPA;Neats;Spectrum of Activity;BIAXIN;Pharmaceutical intermediates
Mol File:	81103-11-9.mol

Clarithromycin Chemical Properties

Melting point	217-220°C
Boiling point	86℃
alpha	D24 -90.4° (c = 1 in CHCl3)
density	1.1334 (rough estimate)
refractive index	-92 ° (C=1, CHCl3)
Fp	>110°(230°F)
storage temp.	-20°C Freezer
solubility	Soluble in DMSO
pka	pKa 8.99(H2O t=25.0 I=0.167) (Uncertain)
color	colorless to faint yellow
Merck	14,2339
Stability:	Store in Freezer
InChIKey	AGOYDEPGAOXOCK-KCBOHYOISA-N

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	26-36-60
RTECS	KF4997000
HS Code	29419000
Toxicity	LD50 in male, female mice, male, female rats (mg/kg): 2740, 2700, 3470, 2700 orally, 1030, 850, 669, 753 i.p., >5000 all s.c. (Abe)

MSDS Information

Provider	Language
6-O-Methylerythromycin	English

Clarithromycin Usage And Synthesis

Chemical Properties	Colourless Crystalline Needles
Uses	A semi-synthetic macrolide antibiotic. A derivative of erythromycin
Uses	Macrolide antibacterial.
Uses	Clarithromycin is a semi-synthetic macrolide antibiotic. Clarithromycin is a derivative of Erythromycin (E650000).
Uses	Clarithromycin (6-methoxyerythromycin) is a macrolide antibiotic active against a broad range of Gram positive bacteria. Clarithromycin was designed to enhance acid stability and improve oral bioavailability compared with erythromycin which is highly unstable to acidic conditions, undergoing a series of internal ketalisations between the 9-keto moiety and alcohols at C6 and C11. Omura and colleagues found that protection of the labile 6-OH group by methylation provided a simple but elegant solution.
Uses	Labeled Clarithromycin, intended for use as an internal standard for the quantification of Clarithromycin by GC- or LC-mass spectrometry.
Uses	A macrolide antibiotic and protein synthesis inhibitor
Definition	ChEBI: The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment f peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.
Hazard	Moderately toxic by ingestion. Human sys-temic effects.

Advantages:

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China Supply Antibacterial Pharmaceuticals Clarithromycin CAS 81103-11-9