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99% Acetyl Chloride 75-36-5 Organic Synthesis Intermediate CAS NO.75-36-5
- Min.Order: 10 Gram
- Payment Terms: T/T,MoneyGram
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- 99% Acetyl Chloride
- Acetyl Chloride Manufacturer
- Organic Synthesis Intermediate
Quick Details
- ProName: 99% Acetyl Chloride 75-36-5 Organic Sy...
- CasNo: 75-36-5
- Molecular Formula: C2H3ClO
- Appearance: White Powder
- Application: It Can Be Used As Pharmaceutical Inte...
- DeliveryTime: 2-4 days after confirming your payment...
- PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
- Port: Wuhan
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Store in sealed containers at cool & d...
- Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
- LimitNum: 10 Gram
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Details
| Acetyl chloride Basic information |
| Product Name: | Acetyl chloride |
| Synonyms: | UN1717 (DOT);Acetyl chloride Ethanoyl chloride;ACETYL CHLORIDE 98% MIN.;Acetyl chloride 99+ % for analysis;Acetyl chloride;Acetyl chloride 99+ % for analysis;ACETYL CHLORIDE, REAGENTPLUS, >=99% ACETYL CHLORIDE, REAGENTPLUS, >=99%;ACETYL CHLORIDE REAGENT GRADE 98%;ACETYL CHLORIDE REAGENTPLUS(TM) >=99% |
| CAS: | 75-36-5 |
| MF: | C2H3ClO |
| MW: | 78.5 |
| EINECS: | 200-865-6 |
| Product Categories: | Pharmaceutical Intermediates;Organics;Nucleosides, Nucleotides & Related Reagents;Protecting Agents for Hydroxyl and Amino Groups;Protecting Agents, Phosphorylating Agents & Condensing Agents;Biochemistry;Organic Chemicals;Chemistry;A-B, Puriss p.a.;Analytical Reagents for General Use;Puriss p.a.;Essential Chemicals;Reagent Grade;Routine Reagents;Reagent Plus;Acid Halides;Carbonyl Compounds;Organic Building Blocks;API Intermediate;organic synthetic raw material;Furans |
| Mol File: | 75-36-5.mol |
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| Acetyl chloride Chemical Properties |
| Melting point | -112 °C |
| Boiling point | 52 °C(lit.) |
| density | 1.104 g/mL at 25 °C(lit.) |
| vapor density | 2.7 (vs air) |
| vapor pressure | 11.69 psi ( 20 °C) |
| refractive index |
n |
| Fp | 40 °F |
| storage temp. | Store at RT |
| solubility | Miscible with acetone, chloroform, glacial acetic acid, petroleum ether, ether and benzene. |
| form | Liquid |
| color | Clear colorless |
| explosive limit | 7.3-19%(V) |
| Sensitive | Moisture Sensitive |
| Merck | 14,85 |
| BRN | 605303 |
| Stability: | Stability Highly flammable. Reacts violently with DMSO, water, lower alcohols, and amines to generate toxic fumes. May form an explosive mixture with air. Note low flash point. Incompatible with water, alcohols, amines, strong bases, strong oxidizing agents, most common metals. |
| InChIKey | WETWJCDKMRHUPV-UHFFFAOYSA-N |
| CAS DataBase Reference | 75-36-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetyl chloride(75-36-5) |
| EPA Substance Registry System | Acetyl chloride(75-36-5) |
| Safety Information |
| Hazard Codes | F,C,Xn |
| Risk Statements | 11-14-34-40-36/38 |
| Safety Statements | 9-16-26-45-1/2-36/37 |
| RIDADR | UN 1717 3/PG 2 |
| WGK Germany | 1 |
| RTECS | AO6390000 |
| F | 3 |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29159080 |
| Hazardous Substances Data | 75-36-5(Hazardous Substances Data) |
| Acetyl chloride Usage And Synthesis |
| Physical and chemical properties | It appears as colorless fuming liquid with a strong odor and eye irritation effect. The relative density of 1.1051 (20 ° C), the melting point of-112 ° C, the boiling point of 51-52 ° C and the flash point is 4.4 ° C (closed dish). In the wet air, it can slowly undergo decomposition and give white smoke. When coming across water, it can be violently hydrolyzed into acetic acid and hydrogen chloride, and thus should be sealed for storage. It is miscible with benzene, acetone, chloroform, ether, glacial acetic acid and petroleum ether. Liquid is heavier than water with the vapor being heavier than air. Its chemical nature is lively. It can have metathesis reaction with many compounds. Acetyl chloride can bind to the thiol group in the protein, and therefore being toxic to humans. It is an important kind of acetylation agents with its acylation capability being stronger than acetic anhydride. It is widely used in organic synthesis, being also the catalyst for the chlorination of carboxylic acids. It is manufactured through the mixing of glacial acetic acid and phosphorus trichloride in cold condition with further heating, followed by dehydrochloration distillation. |
| Dangerous situation |
(1) It has corrosive effect against the skin and mucous membranes with strong irritant effect on the eyes. (2) It is easily flammable with the burning point being 390 ℃ and a greater risk of combustion. Its vapor can form an explosive mixture with air with the explosion limit remaining not be determined. Since the vapor is heavier than air, it can spread to a considerable distance and cause ignition of a source of fire and further propagate the flame back. It can have violent reaction when coming across water and alcohol. When being heated to decomposition, it can release HCl and highly toxic phosgene gas. |
| The main purpose |
Acetyl chloride is the most commonly used acetylating agent with reaction with alcohol and phenol generating acetate ether. Its reaction with ammonia can generate acetamide with its interaction with primary amine and secondary amine to generate N-substituted acetamide. It can be used for the manufacturing of pharmaceutical industry, pesticide manufacturing, acetyl derivatives and dyes. It can be used as the reagents for the determination of phosphorus, cholesterol, water content contained in organic solvents, nitroso, hydroxyl and tetraethyl lead. Acetyl chloride is the most important acyl halide and can be manufactured through the reaction between glacial acetic acid and thionyl chloride or phosphorus trichloride and phosphorus pentachloride. The above information is edited by Andy from ChemicalBook. |
| Harmful effects and symptoms of poisoning | Acetyl chloride is a kind of stimulant and corrosive with contact with the skin being able to cause burns. Its steam can strongly irritate the eye and mucous membranes. Human’s inhalation of 2 ppm will be able to feel stimulating effect. Short-term exposure to higher concentrations of acetyl chloride may cause death or permanent damage. The poisoning amount of the aquatic animal is estimated to be in the range of 10 to 100 ppm. |
| Chemical properties | It appears as colorless transparent liquid smoke with irritating smell. It is miscible with ether, acetic acid and benzene. |
| Uses |
1. It is a kind of acetylating agent, being used as raw materials for pesticides and medicine, or the intermediates for the manufacturing of water treatment agent ethylidene diphosphate. 2. It can be used for the analysis of reagents as well as used for the preparation of acetyl derivatives and dyes 3. It can be used for organic synthesis, dyes and pharmaceutical industries 4. It can be used as the raw materials of pesticides and pharmaceutical as well as the intermediate for the manufacture of water treatment agent ethylene diphosphate. Moreover, it can also be used for the manufacture of new electroplating complexing agent. Acetyl chloride is an important acetylating agent with the acylation capability being stronger than acetic anhydride. It is widely used in organic synthesis and dyes. It is also the catalyst for the carboxylic acid to have chlorination reaction as well as being used for hydroxyl and amino quantitative analysis. 5. This product can be used as raw material for organic synthesis, used in the production of pesticides, pharmaceuticals, new electroplating complexing agent, the catalyst for carboxylic acid to have chlorination, acetylation agent, and other kinds of fine organic synthesis intermediates. |
| Production method |
Industrial, acetyl chloride can be manufactured through the reaction between ethylene with hydrogen chloride, or the reaction between sodium acetate, sulfur dioxide and chlorine. The laboratory can apply acetic acid, sodium acetate or acetic anhydride to have reaction with a variety of chlorination agents. For example, it can be obtained through the reaction between acetic anhydride with chlorosulfonic acid (or hydrogen chloride, carbon tetrachloride, phosgene); or obtained through the reaction between glacial acetic acid and benzoyl chloride (or silicon tetrachloride, phosphorus trichloride, chlorinated sulfurous acid and phosphorus pentachloride,). OPERATION EXAMPLE 1: Ingredient ratio (molar ratio): glacial acetic acid: phosphorus trichloride = 3: 1.2. Glacial acetic acid was added to the reactor and stirred slowly. Phosphorus trichloride was added drop-wise over 10-15 min at room temperature. The reaction mixture is subjecting to heating to increase reaction temperature and subject to reaction being maintained at 40-50 °C for 0.5 h. The reaction product is static with the separation obtaining crude product of acetyl chloride and the yield of about 70%. Operation Example 2 Into a 3 L three-necked flask, add 360 g (6 mol) of glacial acetic acid and 552 g of toluene; heat to 50 °C, and add dropwise 510 g (3 mol) of silicon tetrachloride over 30 min. Keep the temperature at 50 ° C to until hydrogen chloride gas stops being released. Then apply fractionation, steam to until the temperature of the top of the column reaches 80-85 ℃ to obtain the crude product. The fine product is further subject to re-distillation. Take the 50-65 °C fractions and obtain 400 g of acetyl chloride with the yield being 85%. Fixed consumption amount of raw materials: glacial acetic acid: 850kg/t, phosphorus trichloride: 1950kg/t. |
| Hazards & Safety Information |
Category Flammable liquids Toxic grading poisoning Acute Toxicity Oral-Rat LD50: 910 mg/kg Dangerous properties of explosives being corrosive to the skin, eyes and mucous membrane; Flammable and hazardous properties it is flammable in case of fire, high temperature and oxidant; at high temperature, it can be subject to decomposition to release toxic phosgene; it can release toxic chloride when coming across water; Storage and transportation characteristics Treasury: ventilation, low-temperature and drying; store separately from oxidants and acids; Extinguishing agent dry powder, dry sand, dry stone powder, carbon dioxide, foam |
| Chemical Properties | colourless to light yellow liquid with a pungent |
| Uses | Acetylating agent; in testing for cholesterol, determination of H2O in organic liquids. |
| General Description | A colorless, fuming liquid with a pungent odor. Density 9.2 lb / gal. Flash point 40°F. Vapor, which is heavier than air, irritates the eyes and mucous membranes. Corrosive to metals and tissue . |
