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Nootropic Raw Powder Pramiracetam CAS 68497-62-1 for Boosting Brain

Basic information:

Chemical name: Pramiracetam
MF: C14H27N3O2
MW: 269.38
CAS: 68497-62-1
Appearance: white powder
Purity: over 99%
Usage: cognitive enhancers

Description:

Pramiracetam is a drug belonging to the racetam family of cognitive enhancers. Pramiracetam may improve memory and enhance learning ability. It also has the potential to treat amnesia and help with brain injuries. Read on to see the potential uses, mechanisms, and side effects of pramiracetam.

What is Pramiracetam

Pramiracetam (also known as Pramistar) is a cognitive enhancer (nootropic) that is synthesized from piracetam, the original racetam, by substituting the amide group in piracetam with a dipropan-2-ylamino ethyl group. This substitution allows pramiracetam to be more potent than piracetam.

Pramiracetam was developed in 1979 by Parke-Davis, a division of the Warner-Lambert pharmaceutical company. Pramiracetam was at first distributed under the brand name Pramistar. Now, it is part of Pfizer, since Warner-Lambert merged with Pfizer in 2000.

Pramiracetam is found to increase rats' object recognition with a significantly lower dose when compared to piracetam. Piracetam required 13 times the dose of pramiracetam to have the same effect.

Pramiracetam Mechanism of Action:

Acetylcholine (ACh) is a neurotransmitter involved in learning and memory. Pramiracetam increased the rate of choline uptake into the rat brain cells by 30 to 37%. Increased uptake of choline provides more choline as a source to build ACh. This effect lasts approximately 24 hours.

Even when rats were given scopolamine, a substance that reduces choline concentration in the brain, treatment with pramiracetam prevented choline depletion.
Nitric oxide is a compound that is known to play a role in memory and learning. Pramiracetam increases nitric oxide production in the brain.

The action of pramiracetam and other racetams depends on adrenal hormone availability. In rats, racetams, including pramiracetam, lost their "memory-improving effect" after the animals had their adrenal glands removed. Inhibition of adrenal hormone production also suppressed the memory-improving effects of pramiracetam in mice.
However, higher levels of adrenal hormones aldosterone or corticosterone (cortisol equivalent) also blocked the memory-improving effects of this drug in mice in a dose-related manner.


 

Specification

What's Pramiracetam

Ever since the discovery of the racetams in the 1970's, the racetam family of compounds has been a compelling route for people trying to improve general cognition, memory, and learning capabilities.

In the world of nootropics, the racetams are the go-to nootropics for boosting brain power. While there is some variety of racetam forms, and not all racetams are as well understood as the parent compound, one of the more widely known and studied is Pramiracetam.

Pramiracetam (N-[2-(dipropan-2-ylamino)ethyl]-2- (2-oxopyrrolidin-1-yl)acetamide) is a GABA-like compound derived from the original racetam. The chemical difference between the two is that Pramiracetam has a dipropan-2-ylaminoethyl group rather than an amide.

Pramiracetam is remarkable for high oral-bioavailability and high potency. For this reason, users take Pramiracetam in smaller doses than it's prototype.

This more potent racetam is sometimes taken as an alternative to weaker racetams for people who don't feel they give them the sense of well-being that they are after or people who don't want to take as much powder as less potent racetams can require.

How Pramiracetam Works

It's believed that Pramiracetam is absorbed within the intestine, finding its way into the bloodstream.

After approximately half hour, it generally reaches its maximum potential. Once it is transported to the brain, it has an effect on Acetylcholine receptor sites. Acetylcholine is a neurotransmitter that has a direct effect on cognitive functions. It is thought that the acetylcholine sites improve in efficiency.

Pramiracetam binds to receptor sites, increasing the efficiency of Acetylcholine in the brain. There is also a significant increase in blood flow within to the brain. When oxygen uptake is increased, there is also an increase in glucose metabolism. This is what may allow users to feel alert and have a sense of clarity.

It is also believed that Pramiracetam may enhance the uptake of choline to the hippocampus. This area of the brain is responsible for memory and spatial navigation.Therefore, learning and memory tend to improve.