High purity CAS NO.66981-73-5 Tianeptine CAS NO.66981-73-5

Superiority

superiority of tianeptine acid:

tianeptine acid is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. chemically it is a tricyclic antidepressant (tca), but it has different pharmacological properties than typical tcas as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., ampa receptors and nmda receptors) and release of bdnf, in turn affecting neural plasticity.

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Hubei Xinrunde Chemical Co., Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredient(s); Nutritional products; Custom synthesis; Contract Manufacturing.

We pride ourelf on our excellent team of well-known engineers, technological persons and young professional staffs to research and develop new process. We are also dedicated to provide custom synthesis and contract research services to industrial and academic entities on a short or long-term basis. In our lab and pilot-plant, compounds can be manufactured in the quantity from a few grams up to tens of kilos and beyond. we can supply the key intermediates for your project, which short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard.

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•about Tianeptine

It is shown that this drug has not only good antidepressant effects, but also less adverse reactions than traditional tricyclic antidepressants, almost no adverse effects on cardiovascular system, no damage to blood, liver and kidney functions, and no sedative effect.

The drug is effective not only for depression, but also for depressive neurosis, chronic alcoholism and post-withdrawal depression.

Long-term use can prevent recurrence.

The results also showed that this drug was also effective for anxiety symptoms, and the reduction rate of HAMA at the end of the 6th week was slightly higher than that of amitriptyline, which was consistent with the literature reports.

All in all, the results showed that this drug has positive anti-depressive effect, less adverse reactions and mild degree.

Patients have good drug tolerance and high compliance, which are suitable for clinical application.

Researchers in Venezuela and the United States reported that the drug (tianeptine) was associated with a sudden and dramatic improvement in clinically severe asthma.

The antidepressant mechanism of TCA is different from that of traditional TCA, which can increase the uptake of 5-HT in synaptic cleft, but has a weak effect on the reuptake of 5-HT and NA.

There may be an effect of increasing the transmission of 5-HT neurons.

It has no affinity for the M receptor, H1, α1 and α2-Na receptors.

The antidepressant efficacy of this product is similar to TCA, and its safety and tolerability are better than TCA(tricyclic antidepressants).

The efficacy is similar to that of the SSRI's fluoxetine.

•notice

After oral administration, the peak time of plasma drug concentration was 1.8h, and t1/2 was 3.14h, which was mainly cleared by biotransformation.

Gastrointestinal tract absorption is rapid and complete.

Rapid distribution was associated with high protein binding levels (about 94%).

Drug molecules are widely metabolized in the liver by β-oxidation and N-demethylation processes.

The clearance of the drug is characterized by a short final half-life of 2.5 hours, with very little excretion of the prototype through the kidneys (8%), and the majority of its metabolites through the kidneys.

Elderly: Pharmacokinetic studies have demonstrated an increase in clearance half-life of 1 hour in older persons (over 70 years of age) on long-term medication.

Patients with liver insufficiency: studies have shown no change in pharmacokinetic parameters in patients with chronic alcoholism even when alcoholism causes cirrhosis.

Patients with renal insufficiency: studies have shown an increase in clearance half-life of 1 hour.