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99% Ketoconazole CAS 65277-42-1 CAS NO.65277-42-1
- Min.Order: 10 Gram
- Payment Terms: T/T,
- Product Details
Keywords
- 99% Ketoconazole
- Ketoconazole Manufacturer
- For Antifungal
Quick Details
- ProName: 99% Ketoconazole CAS 65277-42-1
- CasNo: 65277-42-1
- Molecular Formula: C26H28Cl2N4O4
- Appearance: White Powder
- Application: It Can Be Used As Pharmaceutical Inte...
- DeliveryTime: 2-4 days after confirming your payment...
- PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
- Port: Wuhan
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Store in sealed containers at cool & d...
- Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
- LimitNum: 10 Gram
Superiority
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
4. Warm after-sale service Any of your question would be solved for the first as soon as possible.
Details
| Ketoconazole Basic information |
| Product Name: | Ketoconazole |
| Synonyms: | ,3-dioxolan-4-yl)methoxy)phenyl)-,cis-;fungarest;fungoral;ketoconazol;ketoderm;ketoisdin;kw-1414;nizoral |
| CAS: | 65277-42-1 |
| MF: | C26H28Cl2N4O4 |
| MW: | 531.43 |
| EINECS: | 265-667-4 |
| Product Categories: | Active Pharmaceutical Ingredients;Organics;Antifungals for Research and Experimental Use;Antitumors for Research and Experimental Use;Biochemistry;Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API;API's;Antifungal;Heterocycles;Isotopically Labeled Pharmaceutical Reference Standard;KETOZOLE |
| Mol File: | 65277-42-1.mol |
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| Ketoconazole Chemical Properties |
| Melting point | 146°C |
| density | 1.4046 (rough estimate) |
| refractive index | -10.5 ° (C=0.4, CHCl3) |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | methanol: soluble50mg/mL |
| pka | pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain) |
| form | Off-white solid |
| color | white to light yellow |
| optical activity | [α]20/D -1 to 1°, c = 4 in methanol |
| Water Solubility | Soluble in DMSO, ethanol, chloroform, water, and methanol. |
| Merck | 14,5302 |
| CAS DataBase Reference | 65277-42-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T,N,F |
| Risk Statements | 25-36/37/38-23/24/25-50/53-48/22-60-39/23/24/25-11 |
| Safety Statements | 36-45-36/37/39-26-61-60-53-36/37-16-7 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TK7912300 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 65277-42-1(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel) |
| Ketoconazole Usage And Synthesis |
| Antifungal drug |
Ketoconazole is a broad-spectrum antifungal imidazole with commercially available product being under the trade name of Jindakening, Meikangling and keNing. It interferes with the activity of fungal cytochrome P-450 with a high selectivity, thus inhibiting the biosynthesis of ergosterol in fungal cell membrane. It is effective in treating both shallow, deep fungal infections and can inhibit both fungal growth and the transition from spores to mycelium to prevent the further infection. It has antifungal effect on Candida genus, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp and Trichophyton. Clinically, it is suitable for the treatment of ringworm, athlete's foot, and skin ringworm, tinea, jock itch, and thrush, tinea versicolor as well as cutaneous candidiasis. Ketoconazole lotion, as a skin external use, is mainly used for clinical treatment and prevention of various kinds of infections caused by Malassezia such as tinea versicolor, seborrheic dermatitis and scalp pityriasis (dandruff), and can quickly alleviate the desquamation and itching caused by seborrheic dermatitis and scalp pityriasis. |
| Uses | It is antifungal drug for being used to treat athlete's foot and excessive dandruff. |
| Production method | Put the mixture containing 2.4 parts of 1-acetyl-4-(4-hydroxyphenyl) piperazine, 0.4 part of 78% sodium hydride, 75 parts of dimethyl sulfate, 22.5 parts of benzene at 40 ℃ for stirring of 1 hour, followed by addition of 4.2 parts of 2-(2,4-dichlorobenzyl-2-(1H-imidazol-1-yl-methyl)-1,3-dioxolane-4-ylmethyl methanesulfonate. Stir at 100 °C overnight with the reaction product resulting in 3.2 parts ketoconazole after treatment. |
| Category | Toxic substances |
| Toxicity grading | Highly toxic |
| Acute toxicity | Oral-rat LD50: 166 mg/kg; Oral-Mouse LD50: 618 mg/kg. |
| Flammability and hazardous characteristics | It is combustible with burning releasing toxic chloride fumes and nitrogen oxides. |
| Storage characteristics | Treasury: ventilation, low-temperature and dry; store it separately from food raw materials. |
| Extinguishing agent | Dry powder, foam, sand, carbon dioxide, water mist. |
| Chemical Properties | White or almost white powder. |
| Uses | antifungal, PXR/SRC1 & CAR/SRC1 inhibitor |
| Uses | For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. |
| Uses | An inhibitor of CYP proteins, thromboxane synthetase, and 5-LO |
| Uses | Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor |