top quality Clobebutyl ester cas#637-07-0 CAS NO.637-07-0

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Clobebutyl ester

Chinese synonyms: alpha-p-oxy-alpha-methyl propionate; alpha-p-oxy-ethyl isobutyrate; antomine; Guanxinping; lipid-lowering ethyl ester; clobebutyl ester; lipid-expelling ethyl ester; Xinxue An

English Name: Clofibrate

English synonyms: (p-chlorophenoxy) dimethyl-aceticaciethylester; 19 more names available; 2-(4-chlorophenoxy) -2-methyl-propanoicaciethylester; 2-(4-chlorophenoxy) -2-methyl-propionicaciethylester; 2-(p-chlorophenoxy) -2-methyl-propionicaciethylester; 2-(p-chlorophenoxy) propanoxy ethyl ester; 2-(p-chlorophenoxy) butyric acid; Acyric ethyl ester; Id, (p-chlorophenoxy) dimethyl-, ethyl ester; alpha-(p-chlorophenoxy) isobutyric acid, ethyl ester

CAS No. 637-07-0

Molecular formula: C12H15ClO3

Molecular weight: 242.7

EINECS No. 211-277-4

Related categories: Aromatics Compounds; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; Intracellular receptor

Mol file: 637-07-0.mol

Characteristic of chlorbexate

Boiling point 154 degrees C

Density 1.14 g/mL at 25 degree C(lit.)

Refractive index n20/D 1.503

Flash point 113 degree C

Storage Conditions 2-8 degrees C

Form liquid

Clear, colorless

Merck 2377

CAS Database 637-07-0 (CAS DataBase Reference)

NIST Chemicals Information Clofibrate (637-07-0)

EPA Chemical Information Propanoic acid, 2-(4-chlorophenoxy) -2-methyl-, ethyl ester (637-07-0)

Application and synthesis of clobetel

Chemical properties colorless or yellow transparent oily liquid, slightly odorous. It is insoluble in water and soluble in ethanol, chloroform and **. The boiling point is 148-150 ((2.67 kPa).

Use of hypolipidemic drugs. It can inhibit the synthesis of cholesterol and triglyceride, increase the excretion of sterols, and reduce the content of ULDL in blood. It is clinically proved that the effect of this product on reducing triglyceride is more obvious than that on lowering cholesterol. When the effect is strong, triglyceride can be reduced by 30-40% and cholesterol can be reduced by 15-20%. It is suitable for type III, IV and V hyperlipidemia, especially for type III, right. In addition, it can reduce the content of plasma fibrinogen and the viscosity of platelets. Therefore, it is beneficial to prevent thrombosis and reduce the incidence of myocardial infarction. It can be used in hyperlipidemia and atherosclerosis. Individual patients taking this product have nausea, vomiting, loss of appetite, abdominal distension, diarrhea and other symptoms. In order to reduce gastrointestinal reactions, small doses should be used at the beginning and gradually increased later, but the prescribed doses should be reached in the first month of treatment. It is better to use the decreasing method when stopping the drug. Use cautiously in patients with liver and kidney insufficiency. Pregnant women should not use it. Toxicity: oral LD50 mice 1.28g/kg, rats 1.65g/kg.

Uses for cerebral thrombosis, cerebral arteriosclerosis, brain trauma sequelae, inner ear vertigo, coronary atherosclerosis and diseases caused by poor peripheral circulation

It is mainly used in the treatment of hyperlipoproteinemia.

According to the raw materials used, there are two main qualified routes for the product. First, p-aminophenol is used as raw material to produce p-phenol by diazotization and substitution, then condensation, hydrolysis and acidification to produce p-phenol.

Oxyisobutyric acid was esterified to acetaminophen. This route takes a long time and the raw material used is unstable but mature. Secondly, phenol was used as raw material to synthesize phenoxyisobutyric acid by condensation, then chlorination and esterification were carried out in ethanol to produce antomine.

Categories of toxic substances

Toxicity grading poisoning

Acute toxicity oral - rat LD50: 940 mg/kg; oral - mouse LD50: 1220 mg/kg

Flammability hazard is flammable; combustion produces toxic chloride smoke; side effects of patient medication are: muscle weakness, muscle spasm, fever

Storage and Transportation Characteristic Ventilation Low Temperature Drying

Fire extinguishing agent dry powder, foam, sand, carbon dioxide, fog water, chlorbainate

Chinese alias butyl ester; ethyl p-oxyisobutyrate; cerebrolyzine; cinnamyzine; cinnamyzine; cinnamophenylpiperazine; clobebutyl ester; cinnamyzine; antomine

English name: Clofibrate

C12H15ClO3 242.70

CAS RN 637-07-0

Physicochemical property density 1.137

Boiling Point 154-156 degrees C

Refractive index 1.503

This product is 2-methyl-2-(4)-

Oxy) ethyl propionate.

The content of C12H15ClO3 should not be less than 98.5%.

Character: This product is a colorless or yellow clarified oily liquid with a special odor. It tastes pungent at first and sweetens afterwards; when exposed to light.

The color deepens gradually.

This product is soluble in ethanol, propanoid, chloroform, ethyl m or petroleum ether, and almost insoluble in water.

The relative density of this product (Appendix VI A) is 1.138-1.144.

The refractive index of this product (appendix VI F) is 1.500-1.505.

Category: Hypolipidemic drugs.