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Home > Products >  99% Chloramphenicol 56-75-7 Antibacterial Antibiotic

99% Chloramphenicol 56-75-7 Antibacterial Antibiotic CAS NO.56-75-7

  • Min.Order: 10 Gram
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Keywords

  • 99% Chloramphenicol
  • Chloramphenicol Manufacturer
  • Antibacterial Antibiotic

Quick Details

  • ProName: 99% Chloramphenicol 56-75-7 Antibacter...
  • CasNo: 56-75-7
  • Molecular Formula: C11H12Cl2N2O5
  • Appearance: White Powder
  • Application: It Can Be Used As Pharmaceutical Inte...
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
  • Port: Wuhan
  • ProductionCapacity: 10000 Metric Ton/Month
  • Purity: 99%
  • Storage: Store in sealed containers at cool & d...
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 10 Gram

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Details

Chloramphenicol Basic information
Description Chemical Properties Uses Antimicrobial Spectrum Mechanism of action Pharmacokinetics Indications resistance Drug interactions Adverse reactions and precautions Methods of production
Product Name: Chloramphenicol
Synonyms: ,[theta-(theta,theta)]-;[R-(R*,R*)]-2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]ethanamide;2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-acetamid;2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,[R-(R*,R*)]-Acetamide;2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamid;Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl);Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-;Acetamide, 2,2-dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-
CAS: 56-75-7
MF: C11H12Cl2N2O5
MW: 323.13
EINECS: 200-287-4
Product Categories: Active Pharmaceutical Ingredients;Antibiotics for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);Antibiotic Explorer;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Pharmaceutical intermediate;CHLOROMYCETIN;antibiotic;Pyridines;Pharmaceutical intermediates
Mol File: 56-75-7.mol
Chloramphenicol Structure
 
Chloramphenicol Chemical Properties
Melting point  148-150 °C(lit.)
alpha  19.5 º (c=6, EtOH)
refractive index  20 ° (C=5, EtOH)
Fp  14 °C
storage temp.  2-8°C
solubility  absolute ethanol: soluble5-20mg/mL (as a stock solution)
form  powder
color  white
Water Solubility  2.5 g/L (25 º C)
Merck  14,2077
BRN  2225532
InChIKey WIIZWVCIJKGZOK-RKDXNWHRSA-N
CAS DataBase Reference 56-75-7(CAS DataBase Reference)
NIST Chemistry Reference Chloramphenicol(56-75-7)
EPA Substance Registry System Acetamide, 2,2-dichloro-N-[(1R,2R)-2- hydroxy-1-(hydroxymethyl)- 2-(4-nitrophenyl)ethyl]-(56-75-7)
 
Safety Information
Hazard Codes  T,F
Risk Statements  45-11-39/23/24/25-23/24/25
Safety Statements  53-45-16-36/37
RIDADR  2811
WGK Germany  3
RTECS  AB6825000
3-10
TSCA  Yes
HazardClass  3
HazardClass  IRRITANT
HS Code  29414000
Hazardous Substances Data 56-75-7(Hazardous Substances Data)
 
Chloramphenicol Usage And Synthesis
Description Chloramphenicol, also known as chlornitromycin, is a broad-spectrum, bacteriostatic antibiotic derived from Streptomyces venezuelae. It is first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. The synthetic product is racemic, also called synthomycin. Syntomycin is a mixture of chloramphenicol L-isomer and d-isomer. Because of dextroisomer antibacterial effect, the effect of synthomycin is only half of the natural products. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It is effective against several gram-positive and gram-negative bacteria and commonly used in researching protein synthesis and to select for chloramphenicol-resistant transformed cells or the bacterial CAT gene.
Chloramphenicol is a semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation.
Chemical Properties It is white or yellowish green needle like crystals. The melting point is 150.5-151.5℃ (149.7-150.7℃). Under the high vacuum it can be sublimated, slightly soluble in water (2.5mg/ml at 25℃), slightly soluble in propylene glycol (150.8mg/ml), soluble in methanol, ethanol, butanol, ethyl acetate, acetone, insoluble in ether, benzene, petroleum ether, vegetable oil. Taste is very bitter.
Uses
  1. Chloramphenicol is used for the treatment caused by typhoid bacillus, dysentery bacillus, Escherichia coli, bacillus, influenza and pneumococcal infections such as brucellosis.
  2. Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.
  3. Chloramphenicol is used to treat serious infections in different parts of the body. It is sometimes given with other antibiotics. However, chloramphenicol should not be used for colds, flu, other virus infections, sore throats or other minor infections, or to prevent infections.
  4. Chloramphenicol should only be used for serious infections in which other medicines do not work. This medicine may cause some serious side effects, including blood problems and eye problems. Symptoms of the blood problems include pale skin, sore throat and fever, unusual bleeding or bruising, and unusual tiredness or weakness.
You and your doctor should talk about the good this medicine will do as well as the risks of taking it .
Chloramphenicol is available only with your doctor's prescription.

Chemical Properties White to grey-white crystalline powder
Uses antibacterial, antirickettsial, inhibits protein synthesis
Uses Chloramphenicol is unusual nitroaromatic metabolite produced by Streptomyces venezuelae, first published in 1947. Chloramphenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Although restricted to ocular use, antibiotic resistance to other classes has refocused attention on this class. Chloramphenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Chloramphenicol has been extensively studied with over 35,000 literature citations.
Uses Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial

 

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