Veterinary Medicine Grade Tiamulin Hydrogen Fumarate CAS 55297-95-5 CAS NO.55297-95-5

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Veterinary Medicine Grade Tiamulin Hydrogen Fumarate CAS 55297-95-5

Tiamulin Basic information

Product Name:	Tiamulin
Synonyms:	TIAMILIN;(3aS,4R,5S,6S,8R,9R,9aR,10R)-Decahydro-8-[[2-(diethylamino)ethyl]thio]acetyloxy-5-hydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1-one;[[2-(Diethylamino)ethyl]thio]acetic acid [(3aS,10R,9aβ)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester;[[2-(Diethylamino)ethyl]thio]acetic acid [(3aS,9aβ,10R)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester;[2-(Diethylamino)ethylthio]acetic acid [(3aS,9aβ,10R)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester;C12065;Tiamulin (100 mg);TiaMulin fuMerate API
CAS:	55297-95-5
MF:	C28H47NO4S
MW:	493.74
EINECS:	259-580-0
Product Categories:	NULL
Mol File:	55297-95-5.mol

Tiamulin Chemical Properties

Melting point	147.5°C
density	1.0160 (rough estimate)
refractive index	1.6550 (estimate)
CAS DataBase Reference	55297-95-5(CAS DataBase Reference)

Safety Information

RTECS	AG9552000
Hazardous Substances Data	55297-95-5(Hazardous Substances Data)

 

Tiamulin Usage And Synthesis

Uses	Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Like pleuromutilin, it inhibits protein synthesis by binding to domain V of 23S rRNA.
Definition	ChEBI: A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) fo the treatment of swine dysentery caused by Serpulina hyodysenteriae.
Safety Profile	Poison by intramuscular and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also MERCAPTANS.

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Veterinary Medicine Grade Tiamulin Hydrogen Fumarate CAS 55297-95-5