Oral Active Pharmaceutical Ingredients Spironolactones 52-01-7 Used as a Diuretic CAS NO.52-01-7

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Product Details

Keywords

52-01-7
Amiloride Hydrochloride
C6H8ClN7O.ClH

Quick Details

ProName: Oral Active Pharmaceutical Ingredients...
CasNo: 52-01-7
Molecular Formula: C6H8ClN7O.ClH
Appearance: powder
Application: Pharmaceutical Intermediate
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 20000 Kilogram/Day
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 100 Gram

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Details

Oral Active Pharmaceutical Ingredients Spironolactones 52-01-7 Used as a Diuretic

Quick detail

Name: Spironolactones
CAS No.: 52-01-7
Formula: C24H32O4S
Molecular Weight: 416.62
Density: 1.24 g/cm3
Melting Point: 207-208 °C(lit.)
Boiling Point: 597 °C at 760 mmHg
Flash Point: 302.3 °C
Solubility: practically insoluble in water
Appearance: White to Off White Solid

Used as a diuretic, lactone (spironolactones), the active metabolite. Inhibition of aldosterone biosynthesis. Wow effect of blockers for Pakistan It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia.

Description

Aldactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.

It also can be used in combination with other drugs to treat elevated blood pressure, and for treating diuretic-induced low potassium (hypokalemia).

Aldactone also is used to counteract the effects of excessive adrenal aldosterone production (hyperaldosteronism). Aldosterone overproduction can occur from a tumor in the adrenal gland or enlarged adrenal glands (hyperplasia of the adrenal glands).

Spironolactones Specification:

Ref. standard	EP8/USP39
Analysis items	Specification	Results
Appearance	white or yellowish-white powder	White powder
Solubility	Practically insoluble in water, soluble in ethanol(96 per cent).	Complies
Identification	A/B/C Meet the requirements	Complies
Specific rotation	- 41 to -46°(EP) / -41 to -45°(USP)	-43°
Loss on drying	Not more than 0.5%	0.08%
Sulfated ash	Not more than 0.1%	0.03%
Impurity A and Impurity C	Not more than 0.2%	N.D
Impurity F and Impurity E	Not more than 0.3%	N.D
Impurity D	Not more than 0.15%	N.D
Impurity I	Not more than 0.5%	N.D
Other arbitrary unknown impurities	Not more than 0.1%	Complies
Total impurities	Not more than 0.7%	0.15%
Ordinary impurities(USP)	Not more than 2.0%	0.05%
Free thiol compounds(EP)	Not more than 0.05 ml	Complies
Free mercapto compounds(USP)	Not more than 0.1ml	Complies
Chromium(EP)	50ppmNot more than 50ppm	Complies
Assay	97.0%~103.0%(USP) / 97.5-102%(EP)	99.9% (USP) / 100.1% (EP)
Fineness	95% Not more than 20 μm	Complies
Conclusion	Qualified

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