Raw Materials Tofacitinib CAS 477600-75-2 CP-690550 Powder CAS NO.477600-75-2

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Keywords

477600-75-2
Tofacitinib
CP-690550

Quick Details

ProName: Raw Materials Tofacitinib CAS 477600-7...
CasNo: 477600-75-2
Molecular Formula: C28H22F3N7O
Appearance: White crystal powder
Application: Anticancer
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 20000 Kilogram/Day
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 100 Gram

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Raw Materials Tofacitinib CAS 477600-75-2 CP-690550 Powder

Introduction:

Product name	Tofacitinib powder
CAS NO.	477600-75-2
Synonym	3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; 3-{(3S,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; CP 690550
MW	312.3696
MF	C16H20N6O
Application	New oral drugs for the occasional method, (tofacitinib the introduction) to selectively inhibit JAK3 signal transduction pathways in cells, inhibition of CD4 T cell proliferation, further blocking interleukin (IL) 17, a gamma interferon, IL - 6, IL - 8 synthesis and secretion of cytokines, such as inhibition of patients with RA synovial fibroblasts proliferation and damaged cartilage further damage.Jak kinase inhibitors, the treatment of rheumatoid arth
Standard	purity:>99%
Appearance	White powder
Shelf life	2 yares

Tofacitinib (INN) is a drug of the janus kinase (JAK) inhibitor class, discovered and developed by the National Institutes of Health and Pfizer. Tofacitinib is marketed as Xeljanz and Jakvinus.

It is currently approved for the treatment of rheumatoid arthritis (RA) in the United States and other countries.

It has demonstrated effectiveness in the treatment of psoriasis in Phase 3 studies. It is being studied for treatment of inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection.

Function:

It is an inhibitor of the enzyme janus kinase 1 (JAK1) and janus kinase 3 (JAK 3) , which means that it interferes with the JAK-STAT signaling pathway, which transmits extracellular information into the cell nucleus, influencingDNA transcription.

In a mouse model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.

Usage:

Rheumatoid arthritis

Phase II clinical trials tested the drug in rheumatoid arthritis patients that had not responded to DMARD therapy. In a tofacitinib monotherapy study, theACR score improved by at least 20% (ACR-20) in 67% of patients versus 25% who received placebo; and a study that combined the drug with methotrexateachieved ACR-20 in 59% of patients versus 35% who received methotrexate alone.

Psoriasis

Tofacitinib is a current investigational drug in psoriasis. Tofacitinib has demonstrated its effectiveness for plaque psoriasis in Phase 3 randomized, controlled trials in comparison to placebo and to etanercept.In particular, a 10 mg twice-daily dose of tofacitinib was shown to be noninferior to etanercept 50 mg subcutaneously twice weekly.

Ulcerative colitis

The phase 3 OCTAVE study of Tofacitinib in ulcerative colitis started in 2012 and completed in 2015.

Vitiligo

In a June 2015 case report, a 53-year-old woman with vitiligo showed noticeable improvement after taking tofacitinib for five months.

Atopic dermatitis

The results of using Tofacitinib in 6 patients with recalcitrant atopic dermatitis was published in the September 2015. All saw improvement in their atopic dermatitis without any adverse events.

Specification:

TEST	SPECIFICATION	RESULT
Character	White to off-white powder	White powder
Identification	A. Infrared absorption B. The retention time of major peak of sample corresponds to that of reference standard	Conforms Conforms
Loss on drying	≤0.8%	0.32%
Residue on Ignition	≤0.1%	0.03%
Related compounds	Impurity A≤0.2% Impurity B≤0.3% Impurity C≤1.0% Any other impurity≤1.0%	0.02% 0.04% 0.06% 0.04%
Residual Solvents	Methanol≤0.3% Acetonum≤0.5% Methylencdichloride≤0.06% MTBE≤0.5% Ethyl acetate≤0.5% Methylbenzene≤0.089%	ND ND ND ND 0.12% ND
Assay	98.0%~101.5%	99.11%
Packaging and storage	Preserve in well-closed container store at controlled room temperature.
Conclusion	All the results conform to the requirement of BP2010.

Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

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