API Chemical Pharmaceutical Intermediate Material High Purity Vandetanib 443913-73-3 CAS NO.443913-73-3

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Product Description:
Product Name: Vandetanib
CAS NO: 443913-73-3
MF: C22H24BrFN4O2
MW: 475.35
EINECS NO: 669-841-4
Description: Vandetanib is a multi-targeted tyrosine kinase inhibitor that not only acts on EGFR, VEGFR and RET tyrosine kinases in tumor cells, but also inhibits other tyrosine kinases as well as serine/threonine kinases . Vandetanib is the first approved treatment for medullary thyroid cancer for the treatment of unresectable, locally advanced or metastatic symptomatic or progressive medullary thyroid cancer.

Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer.

Function:
Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of the thyroid gland. Vandetanib acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase.Vandetanib was the first drug to be approved by FDA (April 2011) for treatment of late-stage (metastatic) medullary thyroid cancer in adult patients who are ineligible for surgery.