high purity Avanafil CAS NO.330784-47-9

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Product Name: Avanafil

CAS: 330784-47-9

MF: C23H26ClN7O3

MW: 483.95

Melting point 150-152°C

density 1.372

storage temp. Sealed in dry,Store in freezer, under -20°C

solubility DMSO (Slightly), Methanol (Slightly, Heated)

pka 11.84±0.46(Predicted)

form Solid

color White to Off-White

Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.

Chemical Properties White Solid

Uses Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.

Uses A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.