- Product Details
Keywords
- 25122-46-7
- Clobetasol propionate
- C25H32ClFO5
Quick Details
- ProName: Clobetasol Propionate Manufacturer 251...
- CasNo: 25122-46-7
- Molecular Formula: C25H32ClFO5
- Appearance: Crystalline Solid
- Application: Topical corticosteroid. Glucocorticoid...
- DeliveryTime: 2-4 days after confirming your payment...
- PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
- Port: Wuhan
- ProductionCapacity: 20 Metric Ton/Week
- Purity: 99%
- Storage: Store in sealed containers at cool & d...
- Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
- LimitNum: 10 Gram
Superiority
Our Adwantage:
1.We have stock so we can delivery quickly at the very day when receive the payment.
2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order.
3.High quality guarenteed, once any problem is found, the package would be reshipped for you
4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air.The most professional forwarder would be recommanded for you.
5. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.Adhering to the principle of customer first conviction.we will provide the best and the most sincere services as possible as we can.
Details
99% Clobetasol Propionate Manufacturer 25122-46-7 for Anti-inflammatory
Basic Information:
CAS: 25122-46-7
Molecular formula: C25H32ClFO5
Molecular weight: 466.97
EINECS: 246-634-3
Content: 98.5-102%
Density: 1.28 g/cm3
Melting Point: 195.5-197 °C
Boiling Point: 569 °C at 760 mmHg
Flash Point: 297.9 °C
Specific rotation: +98 - +104 °C
Packing: 1kg/aluminum foil bag
Appearance: white crystalline powder
COA:
Item |
Specification |
Result |
Appearance |
White to cream, crystalline powder |
White crystalline powder |
Identification (by IR) |
Conforms to the CRS spectrum |
Conforms |
Melting Point |
Approximately 196 °C |
196°C |
Specific rotation |
+98°~+104°(dried substance) |
+99.7° |
Loss on drying |
≤2.0% |
0.2% |
Residue on ignition |
≤0.1% |
0.06% |
Heavy metals |
≤20ppm |
Conforms |
Related substance (by HPLC) |
Any impurity ≤1.0% |
0.22% |
|
Total impurities ≤2.0% |
0.31% |
Assay(by HPLC) |
Contains 97.0% to 102% of C25H32CIFO5 calculated on dried basis |
99.9% |
Residual solvents |
Ethanol ≤3000ppm |
262ppm |
|
Aceton ≤500ppm |
Undetected(LOD 4ppm) |
|
Pyriding ≤100ppm |
Undetected(LOD 3ppm) |
|
N,N-Dimethylformamide ≤100ppm |
Undetected(LOD 10ppm) |
Conclusion |
Meet the specification according to USP35 |
Description:
Clobetasol Propionate is a derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.
Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.
Clobetasol propionate is a corticosteroid of synthetic steroid used to treat various skin disorders including inflammation, itching, herpes labialis, eczema, psoriasis and lichen sclerosus. Clobetasol propionate is also highly effective for contact dermatitis caused by exposure to poison ivy/oak and auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). Clobetasol propionate is used as first-line treatment for both acute and chronic GVHD of the skin.
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Application:
1, clobetasol propionate is a synthetic high topical glucocorticoid drugs. Has a strong anti-inflammatory, anti itching and capillary vascular contraction, the anti-inflammatory effects of hydrocortisone is about 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. At the same time with inhibition of cell mitosis, can effectively penetrate into the skin stratum corneum.
2, external apply to chronic eczema, neurodermatitis, psoriasis and palmoplantar pustulosis, lichen planus, discoid lupus erythematosus, glucocorticoid, topical treatment of pruritic effective and non infectious inflammatory skin disease.
3, has the inhibitory effects of anti-inflammatory, anti allergic, anti proliferation, immune.Can compound products: ketoconazole. Miconazole nitrate, vitamin A acid cream and liniment.
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
4. Warm after-sale service Any of your question would be solved for the first as soon as possible.