Clobetasol Propionate / Dermovate of Anti-Inflammatory 25122-46-7

1.  Quick Detail:
 
Clobetasol propionate
Other names: chlorine betamethasone propyl acetate, clobetasol clobetasol, anthracene, skin, beclomethasone, clobetasol propionate, two clobetasol propionate meters pine, clobetasol propionate, chlorine times dipropionate
Chemical name: 16 beta methyl -11 beta hydroxy -17- (1- oxo propyl) -9- fluoro -21- chlorine - pregnane -1,4- diene -3,20- two ketone; 21-Chloro-9-fluoro-11b, 17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate
CAS number: 25122-46-7
Molecular formula: C25H32ClFO5
Molecular weight: 466.97
Content: 98.5-102%
Standard level: USP32
Melting point: About 196 DEG C
Specific rotation: +98 - +104 C
Packing: 1kg/aluminum foil bag
Appearance: white crystalline powder
Use:1, clobetasol propionate is a synthetic high topical glucocorticoid drugs. Has a strong anti-inflammatory, anti itching and capillary vascular contraction, the anti-inflammatory effects of hydrocortisone is about 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. At the same time with inhibition of cell mitosis, can effectively penetrate into the skin stratum corneum.
2, external apply to chronic eczema, neurodermatitis, psoriasis and palmoplantar pustulosis, lichen planus, discoid lupus erythematosus, glucocorticoid, topical treatment of pruritic effective and non infectious inflammatory skin disease.
3, has the inhibitory effects of anti-inflammatory, anti allergic, anti proliferation, immune.Can compound products: ketoconazole. Miconazole nitrate, vitamin A acid cream and liniment.

2.  Description:
 

Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules).
 
Clobetasol propionate is marketed and sold worldwide under numerous names including Clobex, Clob-x (Colombia),Clovate, Cormax (Watson, US), Pentasol (Colombia), Cosvate (India), Temovate (US), Dermovate (GlaxoSmithKline, Pakistan, Portugal, Israel), Olux, Tenovate, Dermatovate, Butavate, Movate, Novate, and Powercort.

 
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