Local Anesthetic Drugs Articaine HCL Raw Powder For Pain Control CAS 23964-57-0 CAS NO.23964-57-0

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 Local Anesthetic Drugs Articaine HCL Raw Powder For Pain Control CAS 23964-57-0

Description

Articaine Hydrochloride,Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia.

Articaine Hydrochloride,In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.

How ot works

Articaine Hydrochloride,Articaine blocks nerve conduction by reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent: it has the highest affinity for the open state, an intermediate affinity for the inactivated state, and the lowest affinity for the resting state.

Articaine Hydrochloride,The degree of neuronal block is affected by the diameter of the nerve. Larger-diameter fibers (touch/pressure/ motor) require higher concentrations of local anesthetic compared with small myelinated fibers (pain afferents).Articaine is lipid soluble, highly protein-bound (94%), and has a dissociation constant (pKa) of 7.8. Articaine is an intermediate-potency, short-acting local anesthetic with a fast onset of action.

Use:

(1) Articaine HCL is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.

(2) In dentistry, articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia.

(3) In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaineworks well.

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Local Anesthetic Drugs Articaine HCL Raw Powder For Pain Control CAS 23964-57-0