Articaine hydrochloride CAS NO.23964-57-0

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Articaine hydrochloride

CAS: 23964-57-0

MF: C13H20N2O3S.ClH

MW: 320.839

EINECS: 245-957-7

Melting point 177-178°

storage temp. Keep in dark place,Inert atmosphere,2-8°C

solubility H2O: soluble20mg/mL, clear

form powder

color white to beige

Stability: Hygroscopic

Description Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to mepivacaine. Most local anesthetics act by abolishing voltage-gated sodium channel currents indiscriminately in all populations of neurons. Articaine is an amide local anesthetic most commonly used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine is reported to modify cardiac action potentials and ion currents only at concentrations higher than the therapeutic range needed to inhibit voltage-gated sodium channels.

Chemical Properties White or almost white, crystalline powder.

Originator Ultracain,Hoechst,W. Germany,1976

Uses Articaine hydrochloride, belonging to the group of amide anesthetics, is a local anesthetic with a short duration of action. It is utilized for regional anesthesia in day-case surgeries such as arthroscopy, hand and foot surgery, and dentistry.