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5-Aza-2'-deoxycytidine Manufacturer 2353-33-5 For Anticancer CAS NO.2353-33-5
- Min.Order: 10 Gram
- Payment Terms: T/T,
- Product Details
Keywords
- 99% 5-Aza-2'-deoxycytidine
- 5-Aza-2'-deoxycytidine Manufacturer
- For Anticancer
Quick Details
- ProName: 5-Aza-2'-deoxycytidine Manufacturer 23...
- CasNo: 2353-33-5
- Molecular Formula: C8H12N4O4
- Appearance: White Powder
- Application: It Can Be Used As Pharmaceutical Inte...
- DeliveryTime: 2-4 days after confirming your payment...
- PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
- Port: Wuhan
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Store in sealed containers at cool & d...
- Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
- LimitNum: 10 Gram
Superiority
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
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Details
| 5-Aza-2'-deoxycytidine Basic information |
| Product Name: | 5-Aza-2'-deoxycytidine |
| Synonyms: | 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one;5-Aza-2'-deoxycytidine,98+%;4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one;Decitabine(NSC127716);Decitabine(5-aza-2'-deoxycytidine,NSC127716);5-Aza-2'-deoxycytidine (Decitabine);5-Aza-2zzhlxy-deoxycytidine (Decitabine);4-aMino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one |
| CAS: | 2353-33-5 |
| MF: | C8H12N4O4 |
| MW: | 228.21 |
| EINECS: | 219-089-4 |
| Product Categories: | analog of cytosine;Intermediates & Fine Chemicals;Pharmaceuticals;Epigenetics;Inhibitor;Deoxycytidine;Anti-cancer&immunity;Inhibitors;API;Bases & Related Reagents;Nucleotides |
| Mol File: | 2353-33-5.mol |
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| 5-Aza-2'-deoxycytidine Chemical Properties |
| Melting point | ~200 °C (dec.) |
| alpha | D22 +68.5° (30 min) +57.8° (6 hr) (c = 0.5 in water) |
| storage temp. | −20°C |
| solubility | acetic acid/water (1:1): 50 mg/mL |
| form | Powder |
| color | White to Off-white |
| Merck | 14,2853 |
| Stability: | Stable. May be light or air sensitive. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 2353-33-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1,3,5-Triazin-2( 1H)-one, 4-amino-1-(2-deoxy-.beta.- D-erythro-pentofuranosyl)- (2353-33-5) |
| Safety Information |
| Hazard Codes | Xn,Xi,T |
| Risk Statements | 22-36/37/38-68-61 |
| Safety Statements | 26-36-36/37 |
| WGK Germany | 3 |
| RTECS | XZ3012000 |
| F | 10-34 |
| 5-Aza-2'-deoxycytidine Usage And Synthesis |
| Indications and Usage | 5-Aza-2’-deoxycytidine, also known as decitabine or 2'-deoxy-5-azacytidine, is a cell cycle S phase-specific drug used to treat myelodysplastic syndromes (MDS.) |
| Mechanisms of Action | Demethylating agents can regulate gene expression by activating tumor suppressor genes and enhancing the differentiation of genes, which help treat MDS. 5-Aza-2’-deoxycytidine is a natural andenosine analogue of 2′-deoxycytidine, known to the be strongest methylation specific inhibitor of DNA. After phosphorylation it can inhibit DNA methyltransferase, reducing DNA methylation, leading to demethylation of tumor cells, which can restore the normal functioning of genes, thus inhibiting tumor cell proliferation and preventing the occurrence of drug resistance. 5-Aza-2’-deoxycytidine inhibits DNA methylation in vitro, but does not affect its synthesis. Moreover, non-proliferating cells are not sensitive to it. 5-Aza-2’-deoxycytidine has anti-tumor activity and is characterized by a dual mechanism based on dose differences. At high concentrations it is cytoxic, while at low concentrations it is demethlyating. |
| Side Effects |
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| Category | toxic substance |
| Toxicity grading | high |
| Acute toxicity | Intravenous – mouse LD50: 22 mg/kg; peritoneal – mouse LD50: 190 mg/kg |
| Flammability Hazardous characteristics | Combustible; produces toxic nitrogen oxide fumes. |
| Storage characteristics | Ventilated, cold, and dry; store away from raw food materials. |
| Fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist. |
| Chemical Properties | white crystalline powder |
| Uses | Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines. |
| Uses | Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively |
| General Description | Fine white crystalline powder. Used as a drug. |
| Air & Water Reactions | Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour . |
| Reactivity Profile | 5-Aza-2'-deoxycytidine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. |
| Fire Hazard | Flash point data for 5-Aza-2'-deoxycytidine are not available. 5-Aza-2'-deoxycytidine is probably combustible. |
| Biological Activity | Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation. |