High quality 220620-09-7 with best price CAS NO.220620-09-7

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Tigecycline
cas 220620-09-7
high quality Tigecycline

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ProName: High quality 220620-09-7 with best pri...
CasNo: 220620-09-7
Molecular Formula: C29H39N5O8
Appearance: White Crystalline Powder
Application: It Can Be Used As Pharmaceutical Inter...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 1000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

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High quality 220620-09-7 with best price

Tigecycline Basic information

Indications and Usage Mechanisms of Action Adverse reaction

Product Name:	Tigecycline
Synonyms:	2-NAPHTHACENECARBOXAMIDE, 4,7-BIS(DIMETHYLAMINO)-9-[[[(1,1-DIMETHYLETHYL)AMINO]ACETYL]AMINO]-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-, (4S,4AS,5AR,12AS)-;(4s,4as,5ar,12as)-4,7-bis(dimethylamino)-9-[(tert-butylamino)acetamido]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-carboxamide;tigecycline;TIGECYCLINE GLYCYLCYCLINE;(4S,4As,5aR,12as)-4,7-Bis(dimethylamino)-9-{(tert-butylamino)acetamido}-3,10,12,12a-octahydrotetracen-2-carboxamide;2-NAPHTHACENECARBOXAMIDE;TIGECYCLINE POWDER;Tegecycline
CAS:	220620-09-7
MF:	C29H39N5O8
MW:	585.65
EINECS:	1308068-626-2
Product Categories:	Antibacterial;API;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical intermediate
Mol File:	220620-09-7.mol

Tigecycline Chemical Properties

Melting point	164-166°C
storage temp.	Amber Vial, -20°C Freezer
Merck	14,9432
CAS DataBase Reference	220620-09-7(CAS DataBase Reference)

Safety Information

Safety Statements	24/25
RIDADR	3077
RTECS	QI7619500
HazardClass	9
PackingGroup	III

MSDS Information

Tigecycline Usage And Synthesis

Indications and Usage	Tigecycline is also called 9-tert-glycylaminomycetine or diclofenac, and it is a new type of venous injection antibiotic with broad-spectrum activities. It is a type of 9-tert-glycylaminomycetine derivative and is the first glycylcine antibiotic. Tigecycline can serve as a second option after failed first-line treatment for multi-drug resistant bacteria, and it is also a new treatment option for patients who are allergic to penicillin or intolerable to other drugs. It can treat patients 18 years old or above with complex skin and skin structure infections or complex abdominal infections such as complex appendicitis, burn infections, abdominal abscesses, deep soft tissue infections, and ulcer infections.
Mechanisms of Action	Tigecycline’s mechanisms of action are similar to those of tetracycline antibiotics, which are binding with bacterial 30S ribosomes to prevent transfer RNA from entering, making it impossible for amino acids to form peptide chains, thus preventing bacterial protein synthesis and limiting bacterial growth. However, tigecycline’s ability to bind with ribosomes is 5 times that of other tetracycline antibiotics, which means that tetracycline’s anti-drug resistance ability is stronger. Tigecycline’s structure is similar to that of minocycline, but tigecycline’s antibacterial activity is much stronger, and bacteria are less likely to develop resistance to it compared to other tetracycline drugs, and it can also act on the methicillin-resistant Staphylococcus aureus. Tigecycline’s antifungal spectrum includes gram-positive bacteria, gram-negative bacteria and anaerobic bacteria. In vitro experiments and clinical trials showed that tigecycline is sensitive to some aerobic gram-negative bacteria (such as Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae and Klebsiella pneumoniae, Acinetobacter baumannii, Aeromonas hydrophila, Citrobacter Enterobacteriaceae, hemorrhagic Pasteurella, Serratia marcescens, and Stenotrophomonas maltophilia). Pseudomonas auruginosa is resistant to tigecycline.
Adverse reaction	The most common adverse effects are nausea and vomiting, which usually happens in the first 1-2 days of treatment and are mild to moderate in intensity. In a positive drug control clinical trial, 35% percent of complex skin and skin structure infection patients using tigecycline experienced nausea, and 20% experienced vomiting; vancomycin/aztreonam use caused 8.9% nausea and 4.2% vomiting. 25.3% of complex abdominal infection patients using tigecycline experienced nausea, and 19.5% experienced vomiting; vancomycin/aztreonam caused 20.5% nausea and 15.3% vomiting.
Chemical Properties	Orange Solid
Uses	antineoplastic
Uses	Tigecycline is a semi-synthetic tetracycline prepared by the introduction of a tert-butylaminoacetamido group into a previously unexplored and un-substituted region of existing tetracyclines. Like other tetracyclines, tigecycline acts by reversibly binding to the 30S ribosomal subunit and inhibits protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. The enhanced activity can be attributed to stronger binding affinity, thus minimising the impact of existing mechanisms of resistance. Tigecycline is regarded as the first of a new class of glycylcyline antibiotics. Critical comparison to the tetracycline class appears to be lacking in the literature.
Uses	A broad spectrum glycylcycline antibiotic
Uses	A glycylcycline antibiotic, used to treat infection by drug resistant bacteria such as Staphylococcus aureus (Staph aureus) and Acinetobacter baumannii.
Definition	ChEBI: Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respe tively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections ca sed by susceptible organisms.

Tigecycline Preparation Products And Raw materials

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