99% Tenofovir Disoproxil Fumarate CAS 202138-50-9 For Treat AIDS Pharma Raw Materials CAS NO.202138-50-9

Min.Order: 100 Gram
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Product Details

Keywords

202138-50-9
Tenofovir Disoproxil Fumarate
C23H34N5O14P

Quick Details

ProName: 99% Tenofovir Disoproxil Fumarate CAS ...
CasNo: 202138-50-9
Molecular Formula: C23H34N5O14P
Appearance: White crystalline granules or powder.
Application: Used as a pharmaceutical intermediates...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 20000 Kilogram/Day
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 100 Gram

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Details

Tenofovir Disoproxil Fumarate CAS 202138-50-9 For Treat AIDS Pharma Raw Materials

1. Description

Tenofovir disoproxil is an antiretroviral medication used to prevent and treat HIV/AIDS and to treat chronic hepatitis B. The active substance is tenofovir, while tenofovir disoproxil is a prodrug that is used because of its better absorption in the gut.

The drug is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is marketed by Gilead Sciences under the trade name Viread(as the fumarate, TDF). As of 2015 the cost for a typical month of medication in the United States is more than 200 USD.

2. Medical Applciation

HIV-1 infection: Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older.[5] This indication is based on analyses of plasma HIV-1 RNA levels and CD4 cell counts in controlled studies of tenofovir in treatment-naive and treatment-experienced adults.

Tenofovir is indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.

3. Tenofovir Disoproxil Fumarate(TDF)

Food Interactions: None

Very well tolerated, side effects are minimal.

Toxicity:

Renal insufficiency(rare)

Must dose adjust with renal failure.

Also has activity against Hepatitis B.

Dosed 300mg QD.

Active against Lamivudine resistant HBV strains.

HBV resistance 1% at one year.

If TDF is stopped, may have HBV hepatitis flare.

Specification Sheet (COA)

Product name	Tenofovir Disoproxil Fumarate	CAS no.		202138-50-9
Items	Specifications		Results
Appearance	A White to off white crystalline powder		White crystalline powder
Solubility	Freely soluble in DMF and in methanol,sparingly soluble in water		Conform
Identification	A). By IR: Positive		Conform
	B). By HPLC: Positive		Conform
Residue on ignition	0.2% max		complies
Water(By K.F)	1.0% max		0.4%
Heavy metals	20ppm max		Conform
Related Substance (by HPLC)	a (Tenofovir): 0.15% max		Not detected
	b (Adenine): 0.15% max		Not detected
	c (Tenofovir isoproxil monoester): 1.0% max		0.29%
	d (Tenofovir Disoproxil ethyl ester):0.15 max		Not detected
	e (Tenofovir isopropyl isoproxil ): 0.3% max		Not detected
	f (Tenofovir Disoproxil carbamate):0.15% max		Not detected
	g (Tenofovir Disoproxil Dimer):0.15%		Not detected
	Any Individual unspecified impuriy:0.1%		0.09%
	Total impurity: 2.0% max		0.40%
Enantiomeric Purity	1.0% max		Not detected
Tenofovir Disoproxil Related compound B	5PPM max		Not detected
Fumaric Acid	17.5~19.0%		18.03%
Residual solvents	Ethanol: 5000ug/g max		1159ug/g
	Isopropyl alcohol: 5000ug/g max		1077ug/g
	Methylene chloride: 600ug/g max		Not detected
	NMP: 530ug/g max		Not detected
Assay (on anhydrous basis)	98.0% to 102.0%		99.25%
Conclusion	Comply with USP34

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