High Quality 99% Erlotinib Hydrochloride/Erlotinib HCl CAS: 183319-69-9 with Best Price CAS NO.183319-69-9

Min.Order: 10 Gram
Payment Terms: T/T,

Product Details

Keywords

Erlotinib HCl
183319-69-9
183319-69-9 Erlotinib HCl

Quick Details

ProName: High Quality 99% Erlotinib Hydrochlori...
CasNo: 183319-69-9
Molecular Formula: C22H24ClN3O4
Appearance: White Crystalline Powder
Application: It Can Be Used As Pharmaceutical Inte...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: shanghai
ProductionCapacity: 1000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

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Details

High Quality 99% Erlotinib Hydrochloride/Erlotinib HCl CAS: 183319-69-9 with best price

Details:

Product Name	Erlotinib Hydrochloride
Synonyms	Erlotinib, Hydrochloride Salt;N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, Tarceva; N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine
CAS	183319-69-9
EINECS	N/A
MF	C22H24ClN3O
MW	429.
Molecular Structure
Assay	99%
Character	White to pale yellow powder
Usage	Selective epidermal receptor (EGFR)-tyrosine kinase inhibitor. Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3.
Packing	1kg/foil bag

Use in Cancer:

Erlotinib hydrochloride is approved to be used alone or with other drugs to treat:

Non-small cell lung cancer (NSCLC).
It is used as first-line treatment for metastatic NSCLC in patients with tumors that have certain

epidermal receptor (EGFR) mutations.
It is used for locally advanced or metastatic NSCLC in patients who have already been treated with chemotherapy.
Pancreatic cancer. It is used with gemcitabine hydrochloride in patients whose disease cannot be removed by surgery or has metastasized.
Erlotinib hydrochloride is also being studied in the treatment of other types of cancer.

COA:

Item of analysis	Standard		Result of analysis
Description	White to pale yellow powder		Conforms
Melting piont	215.0-227.0ºC		219.0-220.0ºC
Identification	A: IR	Conresponding to reference spectrum	Conresponding to reference spectrum
	B : HPLC	Conresponding to reference RT	Conresponding to reference RT
Loss on drying	≤0.5%		0.31%
Residual on lgnition	≤0.5%		0.19%
Residual solvent	pyridine	≤4000ppm	ND
	DMF	≤3000ppm	ND
	Chloroform	≤4000ppm	ND
Ordinary impurities	Total impurities≤2.0%		0.30%
Assay	98.0%~101.0%		99.7%

Application:

Erlotinib hydrochloride (the trade name Tarceva) is a directly acting inhibitor of epidermal

receptor (EGFR/HER-1) tyrosine kinase with an IC50 of 2 nM.
Epidermalr receptor (EGFR) is one member of the ErbB family which includes EGFR (ErbB1), ErbB2, ErbB3 and ErbB4. The activation of EGFR is dependent on the binding of peptide to the receptor. In many carcinomas, the presence of EGFR mutation leads to the activation of EGFP, which causes cell proliferation and other cancer processes.
Selective inhibition of EGFR tyrosine kinase by erlotinib hydrochloride leads to the disruption of cancer growth and development which include cell migration, proliferation, angiogenesis, and apoptosis. For instance, erlotinib hydrochloride was shown to induce cell apoptosis and G0/G1 cell cycle arrest in hepatocellular cancer cells, Bxpc-3 and PANC-1 cells, thereby enhancing chemosensitivity towards cytostatics.
In addition, this product is widely researched and used for the treatment of human advanced non-small cell lung cancer (NSCLC). In pancreatic cancer, erlotinib hydrochloride was also reported to exhibit an anti-tumour effect.

Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.

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High Quality 99% Erlotinib Hydrochloride/Erlotinib HCl CAS: 183319-69-9 with Best Price