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Home > Products >  High Quality 99% Erlotinib Hydrochloride/Erlotinib HCl CAS: 183319-69-9 with Best Price

High Quality 99% Erlotinib Hydrochloride/Erlotinib HCl CAS: 183319-69-9 with Best Price CAS NO.183319-69-9

  • Min.Order: 10 Gram
  • Payment Terms: T/T,
  • Product Details

Keywords

  • Erlotinib HCl
  • 183319-69-9
  • 183319-69-9 Erlotinib HCl

Quick Details

  • ProName: High Quality 99% Erlotinib Hydrochlori...
  • CasNo: 183319-69-9
  • Molecular Formula: C22H24ClN3O4
  • Appearance: White Crystalline Powder
  • Application: It Can Be Used As Pharmaceutical Inte...
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
  • Port: shanghai
  • ProductionCapacity: 1000 Metric Ton/Month
  • Purity: 99%
  • Storage: Store in sealed containers at cool & d...
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 10 Gram

Superiority

1. Guaranteed purity;

2. Large quantity in stock;

3. Largest manufacturer;

4. Best service after shipment with email;

 

5. High quality & competitive price;

 

Details

High Quality 99% Erlotinib Hydrochloride/Erlotinib HCl CAS: 183319-69-9 with best price

 

 Details:


Product Name Erlotinib Hydrochloride
Synonyms

Erlotinib, Hydrochloride Salt;N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, Tarceva;

N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine;

[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine

CAS 183319-69-9
EINECS N/A
MF C22H24ClN3O
MW 429.
Molecular Structure  
Assay 99%
Character White to pale yellow powder
Usage Selective epidermal  receptor (EGFR)-tyrosine kinase inhibitor. Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3.
Packing 1kg/foil bag

 


 Use in Cancer:


Erlotinib hydrochloride is approved to be used alone or with other drugs to treat:

Non-small cell lung cancer (NSCLC).
It is used as first-line treatment for metastatic NSCLC in patients with tumors that have certain

epidermal receptor (EGFR) mutations.
It is used for locally advanced or metastatic NSCLC in patients who have already been treated with chemotherapy.
Pancreatic cancer. It is used with gemcitabine hydrochloride in patients whose disease cannot be removed by surgery or has metastasized.
Erlotinib hydrochloride is also being studied in the treatment of other types of cancer.


 COA:


Item of analysis Standard Result of analysis
Description White to pale yellow powder Conforms
Melting piont 215.0-227.0ºC 219.0-220.0ºC
Identification A: IR Conresponding to reference spectrum Conresponding to reference spectrum
  B : HPLC Conresponding to reference RT Conresponding to reference RT
Loss on drying ≤0.5% 0.31%
Residual on lgnition ≤0.5% 0.19%
Residual solvent pyridine ≤4000ppm ND
  DMF ≤3000ppm ND
  Chloroform ≤4000ppm ND
Ordinary impurities Total impurities≤2.0% 0.30%
Assay 98.0%~101.0% 99.7%

 


Application:

Erlotinib hydrochloride (the trade name Tarceva) is a directly acting inhibitor of epidermal

receptor (EGFR/HER-1) tyrosine kinase with an IC50 of 2 nM.
Epidermalr receptor (EGFR) is one member of the ErbB family which includes EGFR (ErbB1), ErbB2, ErbB3 and ErbB4. The activation of EGFR is dependent on the binding of peptide  to the receptor. In many carcinomas, the presence of EGFR mutation leads to the activation of EGFP, which causes cell proliferation and other cancer processes.
Selective inhibition of EGFR tyrosine kinase by erlotinib hydrochloride leads to the disruption of cancer growth and development which include cell migration, proliferation, angiogenesis, and apoptosis. For instance, erlotinib hydrochloride was shown to induce cell apoptosis and G0/G1 cell cycle arrest in hepatocellular cancer cells, Bxpc-3 and PANC-1 cells, thereby enhancing chemosensitivity towards cytostatics.
In addition, this product is widely researched and used for the treatment of human advanced non-small cell lung cancer (NSCLC). In pancreatic cancer, erlotinib hydrochloride was also reported to exhibit an anti-tumour effect.

  

Advantages:
 

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
 
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
 
2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
 
3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
 
4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

 

 

 

High Quality 99% Erlotinib Hydrochloride/Erlotinib HCl CAS: 183319-69-9 with Best Price

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