• Mr.Bruce Li
    Tel: +8618874586545

  • Ms.Linda Yang
    sales
    Tel: +8618874586545

  • Ms.Niyoe Tan
    sales
    Tel: 17720330692

  • Mobile:
  • Tel:+8618874586545
  • Fax:02783214688
  • URL:http://xrdchem.lookchem.com/
  • Province/state:Hubei
  • City:Wuhan
  • Street:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China
  • MaxCard:
Home > Products >  Valganciclovir hydrochloride CAS NO 175865-59-5

Valganciclovir hydrochloride CAS NO 175865-59-5 CAS NO.175865-59-5

  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,MoneyGram
  • Product Details

Keywords

  • 175865-59-5
  • Valganciclovir hydrochloride
  • Valganciclovir hydrochloride CAS NO 175865-59-5

Quick Details

  • ProName: Valganciclovir hydrochloride CAS NO 1...
  • CasNo: 175865-59-5
  • Molecular Formula: C14H23ClN6O5
  • Appearance: White powder
  • Application: Pharmaceutical intermediates
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: According to customer's requirement
  • Port: Wuhan
  • ProductionCapacity: 20000 Kilogram/Day
  • Purity: 99%
  • Storage: Store in sealed containers at cool & d...
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 1 Kilogram

Superiority

Advantages:
 

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

 
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
 
2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
 
3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
 
4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

 

Valganciclovir hydrochloride  CAS NO 175865-59-5

Details

 

 

Valganciclovir hydrochloride Basic information
Product Name: Valganciclovir hydrochloride
Synonyms: Valganciclovir-d5 HCl (Mixture of Diastereomers);Ro 107-9070/194;Rs 079070-194;Unii-4p3T9qf9nz;Valcyt;Valcyte;Valganciclovir hydrochlorid;Valganciclovir Hydrochloride (500 mg)
CAS: 175865-59-5
MF: C14H23ClN6O5
MW: 390.82
EINECS: 641-360-4
Product Categories: Pharmaceuticals;CLEOCIN;API;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides
Mol File: 175865-59-5.mol
Valganciclovir hydrochloride Structure
 
Valganciclovir hydrochloride Chemical Properties
Melting point  162-164°C
storage temp.  Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility  H2O: ≥8mg/mL
form  powder
color  white to tan
CAS DataBase Reference 175865-59-5
 
Safety Information
WGK Germany  3
MSDS Information
 
 
Valganciclovir hydrochloride Usage And Synthesis
Description Valganciclovir hydrochloride, a prodrug of the antiviral ganciclovir, was launched in the US for the oral treatment of cytemegalovirus (CMV) retinitis, a sight-threatening complication in patients with AIDS. This L-Valyl ester prodrug can be prepared in three steps from the nucleoside analog ganciclovir by trimethylsilyl-protection of the amino group, coupling with N-benzyloxycarbonyl-L-valine-N-carboxyanhydride, hydrolysis with hydrochloric acid and hydrogenolysis of the Cbz-protecting group. Valganciclovir is well absorbed and rapidly hydrolyzed to ganciclovir by intracellular esterases in the intestinal mucosal cells and by hepatic esterases. Unlike ganciclovir, valganciclovir was demonstrated to be actively transported by the intestinal peptide transporter PEPT1 in Caco-2 cells. As a consequence, its absolute bioavailability in human was 10-fold higher compared to ganciclovir (6%). In clinical trials, it was shown that a twice-daily 900 mg dose of valganciclovir resulted in similar systemic ganciclovir exposure to 5 mg/kg twice-daily intravenous injection of ganciclovir. Valganciclovir concentrations could not be quantified in most patients within three to four hours. In a randomized non-blind phase III clinical trial, oral valganciclovir (900 mg twice daily for three weeks then 900 mg once daily for one week) was as effective as intravenous ganciclovir (5 mg/kg twice daily for three weeks then 5 mg/kg once daily). Oral treatment with valganciclovir avoided catheter-related infection that sometimes occurred with intravenous ganciclovir.
Chemical Properties White Crystalline Solid
Originator Roche (Switzerland)
Uses A pro-drug of ganciclovir. Used in treatment of retro-virus
Uses antibacterial, inhibits protein synthesis
Uses Valganciclovir is the valyl ester prodrug of ganciclovir , an antiviral agent used for the treatment of HIV associated retinitis and for the prevention of post transplant cytomegalovirus (CMV) infections. Upon oral administration, intestinal and hepatic esterases rapidly convert valganciclovir to ganciclovir, which can inhibit viral DNA synthesis (IC50 = 0.95 μM) by targeting the CMV polymerase.

 

Valganciclovir hydrochloride  CAS NO 175865-59-5

Other products of this supplier

lookchemhot product CAS New CAS Cas Database Article Data Chemical Catalog