Synthetic Oxazolidinone Antibiotics Drugs CAS 165800-03-3 APIs Linezolid powder

Description

Product Name	Linezolid
CAS number	165800-03-3
Molecular formula	C16H20FN3O4
Molecular weight	337.35
Appearance	White Solid
Melting point	176-178ºC
Boiling point	585.5ºC at 760 mmHg
Flash point	307.9ºC
Vapour pressure	1.08E-13mmHg at 25°C
Relative density	1.302 g/cm3
Water solubility	N/A

Function

1. Infections caused by vancomycin-resistant Enterococcus faecium, including concurrent bacteremia;
2. Hospital-acquired pneumonia (hap), pathogenic bacteria are Staphylococcus aureus (methicillin-sensitive or methicillin-resistant bead) or Streptococcus pneumoniae (including multidrug resistant strains [mdrsp]). If a gram-negative pathogenic infection has been confirmed or suspected, it is clinically necessary to combine the use of anti-gram-negative bacteria;
3. Complex skin or skin soft tissue infections (ssti), including diabetic foot infections without concomitant osteomyelitis, by Staphylococcus aureus (methicillin-sensitive or methicillin-resistant beads), Streptococcus pyogenes, or non-porous Streptococcus caused. No linezolid has been used for the treatment of acne.
4. Non-complex skin or skin soft tissue infections caused by Staphylococcus aureus (only methicillin-sensitive bacterial beads);
5. Community-acquired pneumonia (caps) and associated bacteremia, from Streptococcus pneumoniae (including multidrug-resistant strains [mdrsp]), or Staphylococcus aureus (methicillin-only bacteria) Caused by beads).

Application

Linezolid is a bacterial protein synthesis inhibitor. Linezolid showed good antibacterial activity against methicillin-sensitive or resistant staphylococci, vancomycin sensitive or resistant enterococci, penicillin-sensitive or resistant to Streptococcus pneumoniae, and antibacterial activity against anaerobic bacteria. Unlike other drugs, linezolid does not affect peptidyl transferase activity. Linezolid has unique sites and modes of action. Therefore, in positive bacteria with essential or acquired resistance characteristics, it is not easy to cross-resist with other antibacterial drugs that inhibit protein synthesis, and it is not easy to induce bacterial resistance in vitro. The production.