Fingolimod hydrochloride(4-fingolimod intermediate),CAS 162359-56-0 ,pharmaceutical CAS NO.162359-56-0

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Fingolimod hydrochloride(4-fingolimod intermediate),CAS 162359-56-0 ,pharmaceutical

Fingolimod hydrochloride Basic information

Oral drug for the treatment of multiple sclerosis

Product Name:	Fingolimod hydrochloride
Synonyms:	Fingolimod (FTY720) hydrochloride;Fin;limod hydrochloride;fingolimod hydrochloride;FTY720;2-AMINO-2-[2-(4-OCTYLPHENYL)ETHYL]-1,3-PROPANEDIOL, HYDROCHLORIDE;2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride;Fingolimod HCl
CAS:	162359-56-0
MF:	C19H34ClNO2
MW:	343.93
EINECS:	1308068-626-2
Product Categories:	All Inhibitors;Inhibitors;Metabolites;Pharmaceutical intermediate;Pharmaceuticals;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;API;Other APIs
Mol File:	162359-56-0.mol

Fingolimod hydrochloride Chemical Properties

Melting point	102-107°C
storage temp.	-20°C Freezer
solubility	water: soluble10mg/mL, clear
color	white to beige
Merck	14,4083
CAS DataBase Reference	162359-56-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-52/53
Safety Statements	26-61
RTECS	TY3130000
HS Code	29221990
Toxicity	LD50 orally in rats: 300-600 mg/kg (Troncoso)

 

Chemical Properties	White Solid
Uses	A derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibitin
Uses	A derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. t is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Uses	Oral medicine for the treatment of multiple sclerosis
Uses	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolong s allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Uses	A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties.

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Fingolimod hydrochloride(4-fingolimod intermediate),CAS 162359-56-0 ,pharmaceutical