Factory Price 99 % GTS-21 CAS NO.156223-05-1

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GTS-21

99% Purity GTS-21 CAS 156223-05-1

GTS-21

CAS No. 156223-05-1

Other Names Nefiracetam

MF: C19H22Cl2N2O2

Grade Pharmaceutical Grade

Shelf Life 2 Years

Transport Package Paper Bag or Drum

Specification

1kg/bag; 25kg/drum

Origin China

HS Code 2942000000

Production Capacity 50kg/Year

  GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective

alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and

cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive

rights to the compound and a related library of analogs as part of the acquisition of Osprey

Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies

in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the

compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study

in healthy adults, GTS-21 also demonstrated cognitive enhancement across all doses, with a

statistically significant improvement in attention related and memory related tasks.

    GTS-21 was O-demethylated to yield compounds that were then subject to glucuronidation.

Three of the metabolites in rat urine were isolated and characterized as 4-OH-GTS-21,

4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. The major urinary metabolites

were 4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. In vitro chemical inhibition

of cytochrome P450 in human liver microsomes indicated that CYPIA2 and CYP2E1 were the

isoforms primarily responsible for the O-demethylation of GTS-21, with some contribution from

CYP3A.