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Home > Products >  99% Diphenhydramine Hydrochloride CAS:147-24-0

99% Diphenhydramine Hydrochloride CAS:147-24-0 CAS NO.147-24-0

  • Min.Order: 10 Gram
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  • 99% Diphenhydramine Hydrochloride
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Quick Details

  • ProName: 99% Diphenhydramine Hydrochloride CAS:...
  • CasNo: 147-24-0
  • Molecular Formula: C17H22ClNO
  • Appearance: White Powder
  • Application: It Can Be Used As Pharmaceutical Inte...
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
  • Port: Wuhan
  • ProductionCapacity: 10000 Metric Ton/Month
  • Purity: 99%
  • Storage: Store in sealed containers at cool & d...
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 10 Gram

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Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

 

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2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


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Details

Diphenhydramine Hydrochloride Basic information
Description Clinical Pharmacology Indications and Usage Drug overdose Contraindications
Product Name: Diphenhydramine Hydrochloride
Synonyms: 2-(diphenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride;2-(diphenylmethoxy)-n,n-dimethyl-ethylaminhydrochloride;Actifed;alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride;alpha-hydroxydiphenylmethane-beta-dimethylaminoethyletherhydrochloride;Ambenyl;BAX;Benacine
CAS: 147-24-0
MF: C17H22ClNO
MW: 291.82
EINECS: 205-687-2
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;BENADRIL;Other APIs;On the central nervous activity inhibition of sedative hypnotic effect;API;Pharmaceutical intermediates
Mol File: 147-24-0.mol
Diphenhydramine Hydrochloride Structure
 
Diphenhydramine Hydrochloride Chemical Properties
Melting point  168-172 °C
Fp  9℃
storage temp.  Desiccate at RT
form  Crystalline Powder or Adhering Crystals
color  White
Water Solubility  1000 g/L
Sensitive  Light Sensitive
Merck  14,3309
Stability: Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.
InChIKey PCHPORCSPXIHLZ-UHFFFAOYSA-N
CAS DataBase Reference 147-24-0(CAS DataBase Reference)
NIST Chemistry Reference diphenhydramine hydrochloride(147-24-0)
EPA Substance Registry System Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride(147-24-0)
 
Safety Information
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7-24/25
RIDADR  2811
WGK Germany  3
RTECS  KR7000000
 
Diphenhydramine Hydrochloride Usage And Synthesis
Description Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
The molecular formula is C17H21NO·HCl and the structural formula is as follows:
Diphenhydramine hydrochloride structural formula
Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.
Clinical Pharmacology Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Detailed information on the pharmacokinetics of Diphenhydramine Hydrochloride Injection is not available.
Indications and Usage Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.
  1. antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
  2. Motion Sickness: For active treatment of motion sickness.
  3. Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.
Drug overdose Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in pediatric patients. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur. Stimulants should not be used. Vasopressors may be used to treat hypotension.
Contraindications
  1. Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.
  2. Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
  3. Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
  4. Antihistamines are also contraindicated in the following conditions: Hyper sensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.
Chemical Properties white crystalline powder
Uses Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.
Uses antihistamine, sedative, treatment of allergic
Uses A histamine H1-receptor antagonist.
Uses H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic
Definition ChEBI: The hydrochloride salt of diphenhydramine.
General Description White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.
Air & Water Reactions Water soluble. Aqueous solutions are acidic.
Reactivity Profile N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light.

 

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