Basic info:

Exenatide acetate
Synonyms: EXENATIDE ACETATE;ENFUVIRTIDE ACETATE;Exenatide;
CAS: 141732-76-5
MF: C186H284N50O62S
MW: 4244.60796
Purity : 99.0%min.
Appearance: White powder
Product Categories: Peptide;Agonist;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
packing:as requirments


Product Description:

A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.

Basic info:

Product name: Exendin-4
Alias: Exenatide Acetate
CAS No.: 141758-74-9
EINECS: 204-035-4
Storage: Shading, confined preservation
Place of Origin: SHANGHAI, China
Molecular Formula: C184H282N50O60 S
Molecular Weight: 4186.66
Purity :99%min
Appearance: White powder
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ± 10% of theoretical
Peptide Content (N%): ≥ 80.0%
Water Content(Karl Fischer): ≤ 10.0%
Acetate Content(HPIC): ≤ 12.0%
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Minimum order quantity: 2mg/vial
Supply Ability: Mass stock
Packaging Details: 2mg/5mg/10mg per vial
Delivery time: 4-6 working days
Usage: Exenatide Acetate can be used to facilitate glucose control.


Application:

Exenatide is believed to facilitate glucose control in at least five ways:

1. Exenatide augments pancreas response and more appropriate amount of insulin that helps lower the rise in blood sugar from eating.
2. Exenatide also suppresses pancreatic release of glucagon, which prevents hyperglycemia (high blood sugar levels).
3. Exenatide helps slow down gastric emptying and thus decreases the rate at which meal-derived glucose appears in the bloodstream.
4. Exenatide has a subtle yet prolonged effect to reduce appetite, promote satiety via hypothalamic receptors.
5. Exenatide reduces liver fat content. Fat accumulation in the liver or nonalcoholic fatty liver disease (NAFLD) is strongly related with several metabolic disorders.