High quality Tetracaine hydrochloride 136-47-0 manufacturer with best service CAS NO.136-47-0

Min.Order: 10 Gram
Payment Terms: T/T,

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ProName: High quality Tetracaine hydrochloride ...
CasNo: 136-47-0
Molecular Formula: C15H25ClN2O2
Appearance: White Powder
Application: It Can Be Used As Pharmaceutical Inte...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

Superiority

High quality Tetracaine hydrochloride 136-47-0 manufacturer with best service

Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

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Details

High quality Tetracaine hydrochloride 136-47-0 manufacturer with best service

Detailed Product Description

Color:	White	Alias:	Tetracaine Hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate Hydrochloride; Amethocaine Hydrochloride
Appearance:	White Powder	Usage:	Mucosa Anesthetic
Type:	Pharmaceutical Raw Materials	Delivery:	DHL, UPS, Fed Ex, Etc

COA of 136-40-3 from.pdf

Local Anesthetic Tetracaine HCl CAS 136-47-0 Tetracaine for Pain Reliever

Quick Details:

Product name: Tetracaine HCl

Synonyms:Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; Amethocaine hydrochloride

CAS : 136-47-0

Molecular formula: C15H25ClN2O2
Molecular weight: 300.82
EINECS: 205-248-5
Appearance: Fine white crystalline and odorless powder
Melting point: 145~150 degree
Assay: 99%
Grade: Pharmaceutical Grade
Usage: Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.

Product Description:

1. Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

2. Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5? (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

3. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt cannulations.

Specifications:

Items	QUALITY STANDARDS	RESULTS
Description	White or almost white crystalline powder	White crystalline powder
Solubility	Matching with the working standard	Complies
Identification	A.By IR, To match with working standard	Complies
	B: To 10ml of solution S add 1ml of ammonium thiocyanate solution R.A white,crystalline precipitate is formed which,after recrystallisation from water R and drying at 80ºC for 2h,melts at about 131ºC	Complies
	C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.A violet colour develops	Complies
	D. Solution S gives reaction of chlorides.	Complies
PH	4.5~6.5	5.78
Residual Solvents	Conform to standard	Complies
Claruty	Solution should be clear	Complies
Related Substances	Conform to standard	Complies
Heavy metals	≤10ppm	<10ppm
Loss on drying	≤1.0%	0.87%
Resiue on ignition	≤0.1%	0.05%
Melting range	148ºC	147.5ºC~150.8ºC
Assay(*)	99%~101.0%	100.40%
Conclusion	The Sample Complies With Specification of EP8

Applications:

1.Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

2.In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.