Ulipristal Acetate Pharmaceutical Raw Materials CAS 126784-99-4 For Contraception CAS NO.126784-99-4

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Ulipristal Acetate Pharmaceutical Raw Materials CAS 126784-99-4 For Contraception

• Quick details of Active Pharmaceutical Ingredients Contraception Ulipristal acetate

Ulipristal acetate

Synonym: EllaOne, Ulipristal ace
CAS: 126784-99-4
M.F.: C28H35NO3
M.W.: 433.5824
Appearance: White crystalline powder
Usage: contraceptive medicine anabolic powder
Storage: Kept Ulipristal acetate in a cool, dry and ventilated place
We guarantee good quality products. 100% refunded if parcel is not delivered or poor quality.

• Introduction of Active Pharmaceutical Ingredients Contraception Ulipristal acetate

Ulipristal acetate (trade name EllaOne in the European Union, Ella in the U.S. for contraception, and Esmya for uterine fibroid) is a selective progesterone receptor modulator (SPRM).

• Medical Uses of Active Pharmaceutical Ingredients Contraception Ulipristal acetate

Emergency contraception:

For emergency contraception a 30 mg tablet is used within 120 hours (5 days) after an unprotected intercourse or contraceptive failure. It has been shown to prevent about 62–85% of expected pregnancies, and prevents more pregnancies than emergency contraception with levonorgestrel. Ulipristal acetate is available by prescription for emergency contraception in over 50 countries, with access through pharmacists without a prescription being tested in the United Kingdom. From July 2016 available without prescription in Israel.

Treatment of uterine fibroids

1. Ulipristal acetate is used for pre-operative treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age in a daily dose of a 5 mg tablet.

2. Treatment of uterine fibroids with ulipristal acetate for 13 weeks effectively controlled excessive bleeding due to uterine fibroids and reduced the size of the fibroids.

3. Two intermittent 3-months treatment courses of ulipristal acetate 10 mg resulted in amenorrhea at the end of the first treatment course in 79.5%, at the end of the second course in 88.5% of subjects. Mean myoma volume reduction observed during the first treatment course (−41.9%) was maintained during the second one (−43.7%). After two to four 3-months courses of treatment, UPA-treated fibroids shown about -70% in volume reduction. This phenomenon was temptatively explained by the combination of multifactorial events involving control of proliferation of the tumor cells, induction of apoptosis and remodeling of the extracellular matrix.

• Technical Test Sheet of Active Pharmaceutical Ingredients Contraception Ulipristal acetate

 
 
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Ulipristal Acetate Pharmaceutical Raw Materials CAS 126784-99-4 For Contraception