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99% Rocuronium Bromide 119302-91-9 Muscle Relaxant CAS NO.119302-91-9
- Min.Order: 10 Gram
- Payment Terms: T/T,MoneyGram
- Product Details
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- 99% Rocuronium Bromide
- Rocuronium Bromide Manufacturer
- Muscle Relaxant
Quick Details
- ProName: 99% Rocuronium Bromide 119302-91-9 Mus...
- CasNo: 119302-91-9
- Molecular Formula: C32H53BrN2O4
- Appearance: White Powder
- Application: It Can Be Used As Pharmaceutical Inte...
- DeliveryTime: 2-4 days after confirming your payment...
- PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
- Port: Wuhan
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Store in sealed containers at cool & d...
- Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
- LimitNum: 10 Gram
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Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
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Details
| Rocuronium bromide Basic information |
| Product Name: | Rocuronium bromide |
| Synonyms: | ROCURONIUM BROMIDE;[3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl] acetate bromide;ROCURONIUN BROMIDE;1-[(2b,3a,5a,16b,17b)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Bromide;Esmeron;Org-9426;Zemuron;Rocuronium Bromide／1-[17B-(acetyloxy)-3a-hydroxy2B-(4-morpholinyl)-5a-androstan-16B-yl]-1-(2-propenyl)pyrrolidinium bromide |
| CAS: | 119302-91-9 |
| MF: | C32H53BrN2O4 |
| MW: | 609.68 |
| EINECS: | 214-776-5 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;Heterocycles;Steroids;Steroid and Hormone |
| Mol File: | 119302-91-9.mol |
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| Rocuronium bromide Chemical Properties |
| Melting point | 162-1640C |
| alpha | D20 +18.7° (c = 1.03 in CHCl3) |
| storage temp. | Room temp |
| solubility | H2O: soluble100mg/mL, clear, light yellow |
| Merck | 14,8246 |
| InChIKey | OYTJKRAYGYRUJK-FMCCZJBLSA-M |
| CAS DataBase Reference | 119302-91-9(CAS DataBase Reference) |
| Rocuronium bromide Usage And Synthesis |
| Non-depolarizing muscle relaxants |
Rocuronium bromide, together with pancuronium, vecuronium, atracurium, and pipecuronium are current commonly used several kinds of clinically non-depolarizing muscle relaxants with Rocuronium bromide having the fastest onset which can provide the ideal conditions of muscle relaxant within 60~90 s. The binding between non-depolarizing muscle relaxants with motor endplate cholinergic receptor will not change the membrane potential of the motion endplate, but instead hinder the binding between acetylcholine and its receptors, and making muscle relaxation occur. The muscle relaxant drugs in the event before, unlike depolarizing muscle relaxants, won’t lead to muscle twitching caused by the contraction of muscle fiber bundles before the occurrence of muscle relaxation. Rocuronium bromide is the derivative of vecuronium, and they have similar role. However, the strength of Rocuronium bromide is only one seventh of that of vecuronium. Intravenous injection of it has a rapid onset, with the cannula can be carried out within 60 to 90 seconds and the action being lasted as long as 30 to 40 minutes. It has no significant effect on vegetation nervous and cardiovascular, but can reduce the intraocular pressure. It has no histamine release effect and sympathetic ganglion blocking effect. It is commonly used in clinical tracheal intubation, can also be used for the maintenance of muscle relaxation in various kinds of surgeries. When being applied to cannula, use a single injection of 0.6mg/kg and a maintenance dose of 0.15mg/kg. This product can have cross-allergic reaction with other muscle relaxants, and thus should be used with caution. Patients of liver and kidney dysfunction and the elderly people should use with caution. |
| Uses | 1. It is a kind of muscle relaxants and a kind of non-depolarizing neuromuscular blocking agents. It is used as the adjuvant drugs for general anesthesia and conventional intubation of both inpatient and outpatient. It can keep the muscle relaxation during the process of mechanical ventilation and surgery. 2. It is used as a kind of skeletal muscle relaxants (non-depolarizing) |
| Production methods | (2α, 3α, 5α, 16α, 17β)-2,3,16,17-diglycidyl androst-17-ol acetate (I) is refluxed together with aqueous solution of pyrrolidine for 1h, resulting in 17-ketone (II ) and sodium borohydride; stir them together in methanol and perform reduction reaction to give compound (III); reflux together with morphine solution for 3d to obtain compound (IV). Partially acetylated, and then reacted with allyl bromide to obtain the product. |
| Chemical Properties | Off-white Solid |
| Uses | Aminosteroid, competitive neuromuscular blocker |
| Uses | A non-depolarizing neuromuscular blocker used in anesthesia to help insert breathing tubes. |