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Home > Products >  99% Tamoxifen 10540-29-1 Treatment Of Advanced Breast Cancer

99% Tamoxifen 10540-29-1 Treatment Of Advanced Breast Cancer CAS NO.10540-29-1

  • Min.Order: 10 Gram
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Keywords

  • 99% Tamoxifen
  • Tamoxifen Manufacturer
  • Treatment Of Advanced Breast Cancer

Quick Details

  • ProName: 99% Tamoxifen 10540-29-1 Treatment Of ...
  • CasNo: 10540-29-1
  • Molecular Formula: C26H29NO
  • Appearance: White Powder
  • Application: It Can Be Used As Pharmaceutical Inte...
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
  • Port: Wuhan
  • ProductionCapacity: 10000 Metric Ton/Month
  • Purity: 99%
  • Storage: Store in sealed containers at cool & d...
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 10 Gram

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Details

Tamoxifen Basic information
Antiestrogen drug Origin of the study Uses Pharmacokinetics Side effects Contraindications Precautions Drug interactions
Product Name: Tamoxifen
Synonyms: (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine;2-[4-[(Z)-1,2-Di(phenyl)but-1-enyl]phenoxy]-N,N-dimethylethanamine;Mammaton;2-[4-[(Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine;2-[p-[(Z)-1,2-Diphenyl-1-butenyl]phenyloxy]-N,N-dimethylethanamine;N,N-Dimethyl-2-[p-[(Z)-1,2-diphenyl-1-butenyl]phenoxy]ethanamine;C07108;Tamoxifen,(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
CAS: 10540-29-1
MF: C26H29NO
MW: 371.51
EINECS: 234-118-0
Product Categories: Aromatics;Active Pharmaceutical Ingredients;Protein Kinase Inhibitors and Activators;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds
Mol File: 10540-29-1.mol
Tamoxifen Structure
 
Tamoxifen Chemical Properties
Melting point  97-98 °C(lit.)
storage temp.  2-8°C
solubility  H2O: insoluble <0.1% at 20°C
Water Solubility  Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.
Merck  13,9137
InChIKey NKANXQFJJICGDU-QPLCGJKRSA-N
CAS DataBase Reference 10540-29-1(CAS DataBase Reference)
EPA Substance Registry System Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1- butenyl]phenoxy]-N,N-dimethyl- (10540-29-1)
 
Safety Information
Hazard Codes  T,Xi
Risk Statements  45-60-61-64-36/37/38
Safety Statements  53-45-36-26
WGK Germany  3
RTECS  KR5919600
Hazardous Substances Data 10540-29-1(Hazardous Substances Data)

Uses 1. Treatment for Women with metastatic breast cancer recurrence. 
2. Used as adjuvant therapy after surgery for breast cancer metastasis, and relapse prevention. 
3. For the treatment of ovarian cancer, endometrial cancer and endometriosis.
Pharmacokinetics This product is easily absorbed orally, generally three hours after taking the drug concentration in the blood is up to the peak; because of enterohepatic circulation, the concentration of product is a more lasting in vivo; in the liver metabolism this product mainly excreted in the feces by biliary (58% to 100% ) rarely excreted in urine (only 2% to 21%); after the anima taking isotopically labeled this product, it is found that radioactivity is the highest in animal ovaries.After it is used for post-menopausal women, the concentration in endometrium is 2 times in plasma .
Side effects 1. Early treatment of bone cancer pain and may be a transient increase, continued treatment can be gradually reduced. 
2. gastrointestinal reactions: loss of appetite, nausea, vomiting, diarrhea. 
3. Reproductive system: menstrual disorders, amenorrhea, vaginal bleeding, genital itching, endometrial hyperplasia, endometrial polyps and endometrial cancer.
4. Skin: facial flushing, rash, hair loss.
5. Bone marrow: occasionally neutropenia and thrombocytopenia.
6. Liver function: occasionally abnormalities.
7. Eyes: using for long time (17 months or more) and large number (240~320mg per day), may appear retinal lesions or corneal opacity .
8. The rare and needed attention of side effects: insanity, pulmonary embolism (showing shortness of breath), thrombosis, weakness, drowsiness.
Contraindications 1. It is contraindicated in patients who are allergic to this product. 
2. It is contraindicated in patients with fundus diseases. 
3. It is contraindicated in patients who have history of deep vein thrombosis and pulmonary embolism or are receiving anticoagulant therapy.
4. It is contraindicated in pregnant woman and nursing mothers.
Precautions 1. Abnormal liver function should be used with caution. If bone metastasis, patients are needed to regularly check blood calcium in the early treatment. 
2.Pregnancy safety of this drug is classified as D class by FDA.
Drug interactions 1. The drug combines with fluorouracil, cyclophosphamide, methotrexate, vincristine and doxorubicin, etc. and can improve the effects. 
2. The drug can increase the dopaminergic effect of bromocriptine mesylate. 
3. The data show that the drug can prolong neuromuscular blockade of atracurium.
4. The drug can enhance the effect of anticoagulants, not combining with anticoagulants (such as warfarin, two coumarin anticoagulants).
5. Antacids and cimetidine, famotidine, ranitidine can change the pH of the stomach, making the drug enteric-coated tablets decomposed and showing a stimulating effect on the stomach, so when l in combination , these drugs should be interval of 1 to 2 hours.
6. Estrogen can affect the therapeutic effect of the drug, should not be combined.
7. The in vitro test results show that the drug may inhibit the metabolism of tacrolimus.
8.When in combination with mitomycin, the risk of hemolytic syndrome and hematuria increased.
9. The drug combines with triptolide which can lead to accelerate tumor growth in mice, so the combination should be cautious.
10. with allopurinol, the drug may increase liver toxicity.
11. The drug combines with other cytotoxic drugs, increasing the risk of thromboembolism.
Chemical Properties White Crystalline Solid
Uses A nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines
Uses Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response mo difiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Uses Tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs91. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation92.

 

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