ISO Manufacturer Supply Hirudin/Hirudin leech extract CAS No .:8001-27-2
Introduction:
Product Name: hirudin
Source: Leech and its salivary glands
Composition: 65-66 amino acids constitute a small molecule protein
Category: Thrombin natural specific inhibitors
Application: Pharmaceutical industry
CAS No .:8001-27-2
Molecular formula: C66H93N13O25
Molecular weight: 1468.53
Hirudin is one of the most active and studied most active components of Leech and its salivary glands. It is a small molecule protein (polypeptide) consisting of 65-66 amino acids. Leech is rich in hirudin, hirudin has a strong inhibitory effect on thrombin, is the strongest thrombin natural specific inhibitors.
hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.
Item
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Specification
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Method Result
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Appearance
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White or Yellowish Powder
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Organoleptic Conforms
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Odour
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Characteristic
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Organoleptic Conforms
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Mesh Size
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100% through 80% mesh size
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USP32<786> Conforms
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Drying Method
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spray drying
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spray drying Conforms
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Ash
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≤5.0%
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Eur.Ph.6.0[2.4.16] 3.26%
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Loss on Drying
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≤5.0%
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Eur.Ph.6.0[2.4.16] 4.39%
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Contaminants
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|
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Pesticides Residue
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Meet USP32<561>
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USP32<561> Conforms
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Lead(Pb)
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≤3.0mg/kg
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Eur.Ph6.0<2.2.58>ICP-MS 2.0
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Arsenic(As)
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≤2.0mg/kg
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Eur.Ph6.0<2.2.58>ICP-MS 1.7
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Cadmium(Cd)
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≤1.0mg/kg
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Eur.Ph6.0<2.2.58>ICP-MS 0.8
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Mercury(Hg)
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≤0.1mg/kg
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Eur.Ph6.0<2.2.58>ICP-MS 0.06
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Microbiological
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|
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Total Plate Count
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≤1000cfu/g
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USP30<61> 180
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Yeast &Mold
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≤500cfu/g
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USP30<61> 138
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E.Coli.
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Negative
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USP30<62> Conforms
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