Formestane Anabolic Steroid Hormones 4-Hydroxyandrost-4-ene-3 17-dione CAS NO.566-48-3

 

 

Formestane Anabolic Steroid Hormones 4-Hydroxyandrost-4-ene-3 17-dione CAS NO 566-48-3

 

Quick Details:

 

 

• Production Name: Formestane
• Alias: 4-Hydroxyandrost-4-ene-3,17-dione
• CAS No: 566-48-3
• Einecs No:219-112-8
• MF:C19H26O3
• MW: 302.41.
• Purity: 99.0%min
• Appearance: white crystalline powder

 

 

 

 
Product Description:
 

 

1.  Formestane (Lentaron) is a type I, steroidal aromatase inhibitor. It is used in the treatment of estrogen-

 

receptor positive breast cancer in post-menopausal women. It is available as an intramuscular depot

 

injection.Formestane has poor oral bioavailability and as such is no longer popular as many orally active

 

aromatase inhibitors have been identified.It is used in the treatment of estrogen receptor-positive breast

 

cancer in postmenopausal women. The drug is not active orally, and is instead available only as and

 

intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase

 

inhibitors have been identified and introduced. Formestane is an analogue of androstenedione.

 

 

2.  Formestane is often used to suppress the production of estrogens from anabolic steroids or

 

prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays

 

weak androgenic activity in addition to acting as a weak aromatase inhibitor.

 

 

3.  Formestane is a androstenedione derivative, and it belongs to an aromatase inhibitor with

 

aminoglutethimide, it is a hormone antineoplastic agent. In physiological conditions, it may competitively

 

inhibit the synthesis of the enzyme leading to estrogen biosynthesis decrease in tissues, then it plays its

 

role in cancer. When the tumor tissue growth relies on the presence of estrogen, in order to inhibit tumor

 

growth, the elimination of tumor estrogen-mediated growth stimulation is necessary.

 

 

4.  This product is more selective than aminoglutethimide while its activity is 100 to 1000 times of

 

aminoglutethimide, and it does not inhibit the synthesis of adrenal hormones,without having to recharge

 

cortisone, etc . The in vitro inhibition of aromatase enzyme of this product is 60 times stronger than

 

aminoglutethimide.

 

 

 
 

 
 
Specifications :
 
 

 

Product name:	Formestane
Other Name:	4-hydroxy-androst-4-ene-17-dione;4-hydroxy-delta(sub4)-androstenedione;4-HYDROXYANDROST-4-ENE-3,17-DIONE;4-HYDROXYANDROSTENEDIONE;4-HYDROXY-4-ANDROSTENE-3,17-DIONE;4-ANDROSTEN-4-OL-3,17-DIONE;4-OHA;CGP-32349;
Original:	China
CAS:	566-48-3
Molecular formula:	C19H26O3
MW:	302.41
Brand name	Xinrunde
Leading time	within 24 hours upon receipt of payment
Delivery	Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity	99%
Package	Discreet and Hidden package according to specific requirement
Appearance	White Powder
Certification	SGS, ISO 9001, KOSHER
Payment Terms	, Money Gram , T/T, Bitcoin
Minimum Order Quantity	5g
Price	Negotiable
Usage	it is primarily used for the treatment of postmenopausal women with advanced breast cancer, it is also effective in prostate cancer.

                                                             
 
 
  Application
 
 

1.  Formestane also known as lentaron,is an anti-cancer drug, it is primarily used for the treatment of

 

postmenopausal women with advanced breast cancer, it is also effective in prostate cancer;

 

 

2.  While it is used alone, the drug can not significantly reduce the pre-menopausal estrogen levels in the

 

blood of women,when it is combined with goserelin (gonadotropin-releasing hormone agonist), its

 

inhibitory effect of estrogen in premenopausal women is greater than goserelin used alone.

 

 

3.  Formestane has no cross-resistance with other aromatase inhibitors , it has no side effects of

 

aminoglutethimide. After oral administration,it is rapidly absorbed by gastrointestinal, its peak plasma

 

concentration time is 1 to 1.5 hours, but the peak concentration of individual is of great difference; after

 

intramuscular injection,it can be accumulated at the injection site and be slowly absorbed.

 

 

4.  It performs Biphasic elimination process, the initial elimination half-life is 2 to 4 days, the terminal

 

elimination half-life is 5 to 10 days. It is mainly metabolized in the liver after oral administration, in the form

 

of glycosides acid metabolites excreted in the urine.