high quality 220127-57-1 Imatinib mesylate with best price CAS NO.220127-57-1

Min.Order: 10 Gram
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220127-57-1
Imatinib mesylate
220127-57-1 Imatinib mesylate

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ProName: high quality 220127-57-1 Imatinib me...
CasNo: 220127-57-1
Molecular Formula: C30H35N7O4S
Appearance: White Crystalline Powder
Application: It Can Be Used As Pharmaceutical Inte...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: shanghai
ProductionCapacity: 1000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

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high quality 220127-57-1 Imatinib mesylate with best price

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Chemical Name	Imatinib Mesylate
CAS NO.	220127-57-1
Synonyms	GLIVEC;GLEEVEC;IMATINIB METHANESULFONATE;CGP-57148B;4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide methanesulfonate;4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate;STI-571;IMATINIB BASE(IMA-3)
Melting point	183-185°C
Molecular Formula	C30H35N7O4S
Molecular Weight	589.71
Boiling Point	754.9 °C at 760 mmHg
Flash point	410.3 °C
Appearance	Off-white solid
Application	Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies

Description

Imatinib, sold under the brand names Gleevec and Glivec, used in the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Due in large part to the development of Gleevec and related drugs having a similar mechanism of action, the five year survival rate for people with chronic myeloid leukemia nearly doubled from 31% in 1993 (before Gleevec's 2001 FDA approval) to 59% for those diagnosed between 2003 and 2009. Median survival for imatinib-treated people with gastrointestinal stromal tumors (GIST) is nearly 5 years compared to 9 to 20 months in the pre-imatinib-era.

Application

A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL)

Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, cKit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. Imatinib also known as Gleevec, Glivec, CGP-57148B, STI-571 & Imatinib.

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