High quality 171596-29-5 Tadalafil in factory CAS NO.171596-29-5

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Keywords

Tadanafil
CAS 171596-29-5 Tadalafil powder
High Purity API tadalafil powder tadalafil pills

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ProName: High quality 171596-29-5 Tadalafil in ...
CasNo: 171596-29-5
Molecular Formula: C22H19N3O4
Appearance: White Crystalline Powder
Application: It Can Be Used As Pharmaceutical Inte...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 1000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

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High quality 171596-29-5 Tadalafil in factory

Tadalafil Basic information

Indications and uses Clinical Research Side effects Warnings and precautions

Product Name:	Tadalafil
Synonyms:	TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351)
CAS:	171596-29-5
MF:	C22H19N3O4
MW:	389.4
EINECS:	200-835-2
Product Categories:	Active Pharmaceutical Ingredients;Cnbio;Erectile Dysfunction;Pyridines ,Halogenated Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Steroid and Hormone;Inhibitor;API;Tadalafil;NUCYNTA
Mol File:	171596-29-5.mol

Tadalafil Chemical Properties

Melting point	298-300°C
alpha	D20 +71.0°
Fp	2℃
storage temp.	Hygroscopic, -20 C Freezer, Under Inert Atmosphere
solubility	DMSO: soluble20mg/mL, clear
color	white to beige
InChIKey	WOXKDUGGOYFFRN-IIBYNOLFSA-N
CAS DataBase Reference	171596-29-5(CAS DataBase Reference)

Safety Information

Hazard Codes	F,Xn
Risk Statements	11-20/21/22-36
Safety Statements	16-36/37
RIDADR	UN 1648 3 / PGII
RTECS	UQ4431050
Hazardous Substances Data	171596-29-5(Hazardous Substances Data)

MSDS Information

Tadalafil Usage And Synthesis

Indications and uses	Cialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.
Clinical Research	In a study of 348 cases of mild to severe erectile dysfunction, patients were randomly given 20mg of Cialis or a placebo. Results showed that in comparison to the placebo group, patients who took Cialis experienced improved intercourse success in the 24-36 hours following medication, with many patients achieving successful sexual intercourse twice in 36 hours. Side effect rate and severity were also no different from those of the placebo group. Over 5% of patients in the Cialis group experienced headaches and indigestion.
Side effects	No severe negative reactions. No perceived facial flushing or sight abnormalities following medication. Rare cases of headache and indigestion.
Warnings and precautions	Patients currently taking nitrates, experiencing angina pectoris, suffering from heart disease, patients who have unregulated hypertension or hypotension, or patients who have had a stroke in the past 6 months should not take Cialis.
Description	Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.
Chemical Properties	White to Off-White Cyrstalline Solid
Uses	analgesic, norepinephrine uptake blocker, mu-opiod receptor agonist
Definition	ChEBI: A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR
Brand name	Cialis (Lilly).
References	# # Roehrborn, C. G., et al. "Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study." Journal of Urology 180.4(2008):1228. Rosano, Giuseppe M. C., et al. "Chronic Treatment with Tadalafil Improves Endothelial Function in Men with Increased Cardiovascular Risk." European Urology 47.2(2005):214-222.

Tadalafil Preparation Products And Raw materials

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