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API Pemetrexed Disodium Manufacturer 150399-23-8 Treatment Of Malignant Pleural Mesothelioma CAS NO.150399-23-8
- Min.Order: 10 Gram
- Payment Terms: T/T,
- Product Details
Keywords
- 99%min Pemetrexed Disodium
- Treatment Of Malignant Pleural Mesothelioma
- API Manufacturer
Quick Details
- ProName: API Pemetrexed Disodium Manufacturer 1...
- CasNo: 150399-23-8
- Molecular Formula: C20H19N5Na2O6
- Appearance: White Powder
- Application: It Can Be Used As Pharmaceutical Inte...
- DeliveryTime: 2-4 days after confirming your payment...
- PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
- Port: Wuhan
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Store in sealed containers at cool & d...
- Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
- LimitNum: 10 Gram
Superiority
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
4. Warm after-sale service Any of your question would be solved for the first as soon as possible.
Details
| Pemetrexed disodium Basic information |
| Product Name: | Pemetrexed disodium |
| Synonyms: | n-[4-[2-(2-amino-4,7-dihydro-4-oxo-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid disodium salt;PEMETREXED DISODIUM;PEMETREXED DISODIUM(ALIMTA);PEMETREXED SODIUM;PEMETREXED;2-[4-[2-(4-Amino-2-oxo-3,5,7-triazabicyclo[4.3.0]nona-3,8,10-trien-9-yl)ethyl]benzoyl]aminopentanedioic acid disodium salt;PEMETREXED DISODIUM 99%;PEMETREXED DISODIUM 2.5H2O |
| CAS: | 150399-23-8 |
| MF: | C20H19N5Na2O6 |
| MW: | 471.37 |
| EINECS: | |
| Product Categories: | Molecular Targeted Antineoplastic;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;LY-231514 |
| Mol File: | 150399-23-8.mol |
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| Pemetrexed disodium Chemical Properties |
| storage temp. | -20°C Freezer |
| CAS DataBase Reference | 150399-23-8(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T;Xi,Xi,T |
| Risk Statements | 36/38-60-61-68 |
| Safety Statements | 36/37/39-53 |
| Pemetrexed disodium Usage And Synthesis |
| Description |
Pemetrexed disodium (marketed as ALIMTA®, “pemetrexed”) is a novel, multi-targeted antifolate. It suppresses tumor growth by impeding both DNA synthesis and folate metabolism. Pemetrexed disodium has demonstrated promising clinical activity in a wide variety of solid tumors, including non-small cell lung, breast, mesothelioma, colorectal, pancreatic, gastric, bladder, cervix, and head and neck. Pemetrexed disodium is approved to be used alone or with other drugs to treat malignant pleural mesothelioma in patients who cannot be treated with surgery and non-small cell lung cancer (certain types) in patients whose disease is locally advanced or has metastasized (spread to other parts of the body). Pemetrexed disodium is also being studied in the treatment of other types of cancer. |
| References |
[1] # [2] Axel-R. Hanauske, V. Chen P. Paoletti, C. Niyikiza (2001) Pemetrexed Disodium: A Novel Antifolate Clinically Active Against Multiple Solid Tumors, The Oncologist, 6, 363-373 |
| Chemical Properties | Crystalline Solid |
| Uses | Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively |
| Uses | Multitargeted antifolate; inhibits thymidylate synthase as well as other folate dependent enzymes. Antineoplastic |
| Definition | ChEBI: An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 4 1 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). |