High Purity Antithrombotic Drugs CAS 141396-28-3 Argatroban with Best Price CAS NO.141396-28-3

 
Introduction:

CAS No.: 141396-28-3

Name: Argatroban monohydrate

Formula: C23H36N6O5S.H2O

Molecular Weight: 526.65

Synonyms:2-Piperidinecarboxylicacid,1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,monohydrate, (2R,4R)- (9CI);2-Piperidinecarboxylic acid,1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,monohydrate, [2R-[1(2S*),2a,4b]]-[partial]-;2-Piperidinecarboxylicacid,1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,hydrate (1:1), (2R,4R)-;

Boiling Point: 801.3 °C at 760 mmHg

Flash Point: 438.4 °C

Specifiacation:

Appliciation:

Argatroban is used as an anticoagulant in individuals with thrombosis and heparin induced thrombocytopenia. Often these individuals require long term anticoagulation. If warfarin is chosen as the long term anticoagulant, this poses particular challenges due to the falsely elevated prothrombin time and INR caused by argatroban. The combination of argatroban and warfarin may raise the INR to greater than 5.0 without a significant increased risk of bleeding complications.One solution to this problem is to measure the chromogenic factor X level. A level < 40-45% typically indicates that the INR will be therapeutic (2-3) when the argatroban is discontinued.