Pharmaceutical Grade Voriconazole 137234-62-9 CAS NO.137234-62-9

Min.Order: 10 Gram
Payment Terms: T/T,

Product Details

Keywords

Voriconazole
137234-62-9
raw material Voriconazole

Quick Details

ProName: Pharmaceutical Grade Voriconazole 1372...
CasNo: 137234-62-9
Molecular Formula: C16H14F3N5O
Appearance: White Crystalline Powder
Application: It Can Be Used As Pharmaceutical Inter...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 1000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

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Pharmaceutical Grade Voriconazole 137234-62-9

Voriconazole Basic information

Product description Pharmacological interactions Uses

Product Name:	Voriconazole
Synonyms:	Voriconazole 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;Voriconazole solution;(2R,3S)-2-(2,4-Difluorophenyl)-3;2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,2,4-triazol-1-yl)butan-2-ol;2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol;Voriconazole, >=98.5%;(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-((1H)-1,2,4-triazol-1-yl)-butan-2-;Voriconazole≥ 99.9% (HPLC, Dried basis)
CAS:	137234-62-9
MF:	C16H14F3N5O
MW:	349.31
EINECS:	200-261-5
Product Categories:	Fine Chemical;antifungal;API;Antifungal (Systemic);Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles;Pfizer compounds;Inhibitor;ZINACEF
Mol File:	137234-62-9.mol

Voriconazole Chemical Properties

Melting point	127-130°C
alpha	D25 -62° (c = 1 in methanol)
Fp	9℃
storage temp.	Store at +4°C
solubility	DMSO: >20mg/mL
Merck	14,10033
InChIKey	BCEHBSKCWLPMDN-MGPLVRAMSA-N
CAS DataBase Reference	137234-62-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	22-36/38-52/53-48/22-40-25-61-39/23/24/25-23/24/25-11
Safety Statements	26-36-45-36/37-22-53-16
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
RTECS	UV9145000
HazardClass	6.1
PackingGroup	III

MSDS Information

Voriconazole Usage And Synthesis

Product description	Voriconazole is a broad-spectrum triazole antifungal ,it is primarily used for the treatment of progressive, possibly life-threatening infections in immune deficiency patients. Indications include: immunosuppressed patients with severe fungal infections, acute invasive aspergillosis (the most common pathogen is Aspergillus fumigatus, followed by A. flavus, Aspergillus niger and Aspergillus soil), severe invasive infections caused by fluconazole-resistant Candida (including C. krusei) severe infection caused by Foot actinomycetes bacteria genus and Fusarium bacteria genus . Moderate to severe renal insufficiency is administered intravenously paying caution.
Pharmacological interactions	Combination With the CYP3A4 substrates, terfenadine, sirolimus, astemizole, cisapride, pimozide or quinidine , can increase blood concentrations of this drug, leading to QT prolongation, and occasionally torsades de pointes ventricular tachycardia. Combination With Rifampicin, rifabutin, efavirenz, ritonavir (each 400mg, once every 12 hours), carbamazepine and phenobarbital, can significantly lower blood concentrations of voriconazole. Combination with ergot alkaloids (ergotamine, dihydroergotamine) plasma concentrations of ergot drugs can cause increased ergot poisoning. The above information is edited by the chemicalbook of Tian Ye.
Uses	broad-spectrum antifungal
Chemical Properties	Cyrstalline Solid
Uses	An antifungal (systemic). An ergosterol biosynthesis inhibitor.
Uses	antibacterial
Uses	An antifungal. An Ergosterol Biosynthesis inhibitor
Definition	ChEBI: A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochr me P450 2C9 (CYP2C9) and CYP3A4.
Uses	Voriconazole is a triazole, antifungal agent that inhibits a broad range of pathogenic yeasts, including Candida (MIC = 0.03-8 μg/ml), and filamentous fungi such as Aspergillus, Scedosporium, and Fusarium. Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.
Brand name	Vfend (Pfizer).
Biological Activity	Triazole antifungal agent. Displays potent activity against Candida , Cryptococcus and Aspergillus species.

Voriconazole Preparation Products And Raw materials

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