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Home > Products >  Pharmaceutical grade Itopride hydrochloride CAS 122892-31-3 Raw Powders

Pharmaceutical grade Itopride hydrochloride CAS 122892-31-3 Raw Powders CAS NO.122892-31-3

  • Min.Order: 100 Gram
  • Payment Terms: T/T,
  • Product Details

Keywords

  • Itopride hydrochloride
  • 122892-31-3
  • heartburn

Quick Details

  • ProName: Pharmaceutical grade Itopride hydrochl...
  • CasNo: 122892-31-3
  • Molecular Formula: C20H27ClN2O4
  • Appearance: white crystalline powder
  • Application: Itopride hydrochloride is an AChE inhi...
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
  • Port: Wuhan
  • ProductionCapacity: 20000 Kilogram/Day
  • Purity: 99%
  • Storage: Store in sealed containers at cool & d...
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 100 Gram

Superiority

1. Guaranteed purity;

2. Large quantity in stock;

3. Largest manufacturer;

4. Best service after shipment with email;

5. High quality & competitive price;

 

Details

 

Pharmaceutical grade Itopride hydrochloride CAS 122892-31-3 Raw Powders

 

 

 

Itopride (INN) is a prokinetic benzamide derivative unlike metoclopramide or domperidone.These drugs inhibit dopamine and have a gastrokinetic effect.Itopride is indicated for the treatment of unctionaldyspepsia and other gastrointestinal conditions.It is a combined D2 receptor antagonist andacetylcholinesterase inhibitor.

Typically, itopride is indicated in the treatment of GI symptoms caused by reduced GI motility:

  • dyspepsia of a non-ulcer/dysmotility type (gastric "fullness", discomfort, and possible pain)
  • gastroparesis (delayed gastric emptying)
  • anorexia
  • heartburn
  • regurgitation
  • bloating
  • nausea and vomiting
  • other possible gastric, prolactin, or dopamine related conditions

Itopride is typically taken three times a day. The dose is usually taken on an empty stomach about an hour before meals. However, the dosage and details of administration may vary depending on the patient's age, symptoms, and other factors.

Itopride was shown to significantly improve symptoms in patients with functional dyspepsia and motility disorders in placebo-controlled trials.

 

These studies concluded that the reduction in the severity of symptoms of functional dyspepsia after 8 weeks of treatment with itopride indicated that itopride was significantly superior to placebo and that itopride yielded a greater rate of response than placebo in significantly reducing pain and fullness.

 

CHEMICAL INFORMATION

 

  • M.Wt: 394.8924
  • Formula: C20H27ClN2O4
  • Purity: 98-100% (actual purity reported on CofA)
  • Solubility: DMSO:52mg/mL
  • Storage: As per the recommended conditions.

BIOLOGICAL ACTIVITY

 

 

  • Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor.
  • Target: AChE Itopride is a gastroprokinetic benzamide derivative. The IC50 of itopride with AChE (2.04 +/- 0.27 microM) was, however, 100-fold less than that with BuChE, whereas in the case of neostigmine with AChE (11.3 +/- 3.4 nM), it was 10-fold less. The inhibitory effect of itopride on cholinesterase (ChE) activity in guinea pig gastrointestine was much weaker than that on pure AChE. the IC50s of itopride against ChE activities were found to be about 0.5 microM. The IC50 of itopride for electric eel and guinea pig gastrointestinal AChE inhibition was 200 times and 50 times as large as that of neostigmine, respectively.

 

 

Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.


1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

 

 

Pharmaceutical grade Itopride hydrochloride CAS 122892-31-3 Raw Powders

 

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