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Glibenclamide Pharma Raw Materials for Antihyperglycemic , CAS 10238-21-8 CAS NO.10238-21-8
- Min.Order: 100 Gram
- Payment Terms: T/T,
- Product Details
Keywords
- 10238-21-8
- Glibenclamide
- C23H28ClN3O5S
Quick Details
- ProName: Glibenclamide Pharma Raw Materials for...
- CasNo: 10238-21-8
- Molecular Formula: C23H28ClN3O5S
- Appearance: white crystalline powder
- Application: Acarbose is an anti-diabetic drug used...
- DeliveryTime: 2-4 days after confirming your payment...
- PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
- Port: Wuhan
- ProductionCapacity: 20000 Kilogram/Day
- Purity: 99%
- Storage: Store in sealed containers at cool & d...
- Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
- LimitNum: 100 Gram
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Details
Glibenclamide Pharma Raw Materials for Antihyperglycemic , CAS 10238-21-8
Details
Name: Glibenclamide
CAS No.: 10238-21-8
EINECS No.: 233-570-6
Molecular Formula: C23H28ClN3O5S
Molecular Weight: 494.01
Melting point: 168-173º C
Appearance: White crystalline powder
Standard: Enterprise Standard
Packing: 25KG/Drum or as per your requirements
Application: Medical use
Descroption
Glibenclamide belongs to the second generation oral sulfonylurea drugs with the mechanism of action being similar as tolbutamide and the hypoglycemic effect being strongest among sulfonylurea drugs. Its intensity of action is about 200 to 250 times of that of Tolbutamide. It can selectively act on the pancreatic β-cells, promote insulin secretion; can enhance the hypoglycemic effect of exogenous insulin and strengthen the post-receptor effect of insulin.
Glibenclamide has fast oral absorption with high protein binding rate. It begins to take effect after 30 minutes with the effect being strongest at 1.5 hours and the duration of 16 to 24 hours. It has a distribution volume of 0.1L / kg, plasma protein binding rate of 90% to 95% and half-life of 4 to 8 hours. It is mainly consumed by the liver metabolism with six metabolites. Two of them are known as hydroxylated compounds with no hypoglycemic effect and is mainly excreted from the urine and a small amount is excreted by the stool. It is clinically mainly used for the treatment of mild to moderate non-insulin dependent diabetes mellitus .
Recently , an international study found that the commonly used diabetes drug glibenclamide can help the body's immune system to fight against certain bacterial infections, e.g. in the treatment of melioidosis, the mortality rate can be reduced by about half.
Melioidosis is a disease prevalent in tropical areas such as Southeast Asia and northern Australia. It is caused by Burkholderia pseudomallei with the symptoms including sepsis and pneumonia. The mortality rate is high. Diabetic patients tend to be more susceptible to melioidosis, but the mortality rate is lower compared with other patients .
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
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Glibenclamide Pharma Raw Materials for Antihyperglycemic , CAS 10238-21-8