Introduction

Fursultiamine (INN; Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor), also known as thiamine tetrahydrofurfuryl disulfide (TTFD), is a disulfide derivative of thiamine, or an allithiamine.It was synthesized in Japan in the 1960s for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B1 deficiency and was subsequently commercialized not only in Japan but also in Spain, Austria,Germany, and the United States. As a vitamin, it is available over-the-counter as well.

In addition to its clinical indication of avitaminosis, fursultiamine has been studied in clinical trials forAlzheimer's disease and autistic spectrum disorders with positive but modest benefits.It has also been investigated in improving energy metabolism during exercise and reducing exercise-induced fatigue with conflicting results.

Fursultiamine is a disulfide derivative of thiamine, or an allithiamine.It was synthesized for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B1 deficiency.

Function

It is a synthetic derivative of thiamine (vitamin B1). As a dimer of two modified thiamine molecules, it is a lipophilic compound that crosses the blood-brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain.

Specification