Local Anesthetic Tetracaine HCl CAS 136-47-0 Tetracaine For Pain Reliever CAS NO.136-47-0

 

COA of 136-40-3 from.pdf

 

Local Anesthetic Tetracaine HCl CAS 136-47-0 Tetracaine for Pain Reliever

 

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Product Description:
 
 

 1. Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

 2. Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5? (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

 

 3. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt cannulations.

 

Specifications:
 
 

 

Items QUALITY STANDARDS RESULTS Description White or almost white crystalline powder White crystalline powder Solubility Matching with the working standard Complies Identification A.By IR, To match with working standard Complies B: To 10ml of solution S add 1ml of ammonium thiocyanate solution R.A white,crystalline precipitate is formed which,after recrystallisation from water R and drying at 80ºC for 2h,melts at about 131ºC Complies C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.A violet colour develops Complies   D. Solution S gives reaction of chlorides. Complies PH 4.5~6.5 5.78 Residual Solvents Conform to standard Complies Claruty Solution should be clear Complies Related Substances Conform to standard Complies Heavy metals ≤10ppm <10ppm Loss on drying ≤1.0% 0.87% Resiue on ignition ≤0.1% 0.05% Melting range 148ºC 147.5ºC~150.8ºC Assay(*) 99%~101.0% 100.40% Conclusion The Sample Complies With Specification of EP8

 
 

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